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Extracellular Volume Fraction Calculated Using Contrast-Enhanced Computed Tomography as a Biomarker of Oxaliplatin-Induced Sinusoidal Obstruction Syndrome: A Preliminary Histopathological Analysis
http://hdl.handle.net/10458/0002000697
http://hdl.handle.net/10458/0002000697100fc597-e4eb-4713-af9a-654d470a9ec2
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2024-08-20 | |||||||||||||||||||
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| タイトル | Extracellular Volume Fraction Calculated Using Contrast-Enhanced Computed Tomography as a Biomarker of Oxaliplatin-Induced Sinusoidal Obstruction Syndrome: A Preliminary Histopathological Analysis | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||
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| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| キーワード | Liver-expressed antimicrobial peptide 2 | |||||||||||||||||||
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| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| キーワード | Ghrelin | |||||||||||||||||||
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| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| キーワード | Bariatric surgery | |||||||||||||||||||
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| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| キーワード | Obesity | |||||||||||||||||||
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| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| キーワード | Diabetes mellitus | |||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||
| アクセス権 | ||||||||||||||||||||
| 著者 |
甲斐, 健吾
× 甲斐, 健吾× 濵田, 剛臣× 佐藤, 勇一郎× 旭吉, 雅秀× 今村, 直哉× 矢野, 公一× Ikeda, Takuto
× Ichihara, Akiko
× Ogata, Shogo
× チヨウジヨウフ, ナランツオツク
WEKO
26967
× 菱川, 善隆× 細川, 歩× 七島, 篤志 |
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Background. Oxaliplatin (OX)-based chemotherapy induces sinusoidal obstruction syndrome (SOS) in the nontumorous liver parenchyma, which can increase the risk of liver resection due to colorectal liver metastasis (CRLM). The extracellular volume (ECV) calculated from contrast-enhanced computed tomography (CT) has been reported to reflect the morphological change of hepatic fibrosis. The present retrospective study aimed to evaluate the ECV fraction as a predictive factor for OX-induced SOS. Methods. Our study included 26 patients who underwent liver resection for CRLM after OX-based chemotherapy with a preoperative dynamic CT of appropriate quality. We investigated the relationship between the pathological SOS grade and the ECV fraction. Results. Overall, 26 specimens from the patients were graded with the SOS classification of Rubbia-Brandt et al. as follows: grade 0, n = 17 (65.4%); grade 1, n = 4 (15.4%); and grade 2, n = 5 (19.2%). No specimens showed grade 3 SOS. In a univariate analysis, the ECV fraction in grade 0 SOS was significantly lower than that in grade 1 + 2 SOS (26.3 ± 3.4% vs. 30.6 ± 7.0%; P = 0.025). The cutoff value and AUC value of the ECV fraction to distinguish between grades 0 and 1 + 2 were 27.5% and 0.771, respectively. Conclusions. Measurement of the ECV fraction was found to be a potential noninvasive diagnostic method for determining early-stage histopathological sinusoidal injury induced by OX-based chemotherapy. |
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| 言語 | en | |||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | Citation: Kai K, Hamada T, Sato Y, Hiyoshi M, Imamura N, Yano K, Ikeda T, Ichihara A, Ogata S, Choijookhuu N, Hishikawa Y, Hosokawa A, Nanashima A. Extracellular Volume Fraction Calculated Using Contrast-Enhanced Computed Tomography as a Biomarker of Oxaliplatin-Induced Sinusoidal Obstruction Syndrome: A Preliminary Histopathological Analysis. J Oncol. 2023 Feb 14;2023:1440257. doi: 10.1155/2023/1440257 |
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| 言語 | en | |||||||||||||||||||
| 書誌情報 |
en : Journal of Oncology 巻 2023, p. 1-8, 発行日 2023-02-14 |
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| 出版者 | ||||||||||||||||||||
| 出版者 | Hindawi Limited | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 1687-8469 | |||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 1687-8450 | |||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.1155/2023/1440257 | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 権利情報 | © 2023 The Author(s). | |||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
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甲斐, 健吾, 濵田, 剛臣, 佐藤, 勇一郎, 旭吉, 雅秀, 今村, 直哉, 矢野, 公一, Ikeda, Takuto, Ichihara, Akiko, Ogata, Shogo, チヨウジヨウフ, ナランツオツク, 菱川, 善隆, 細川, 歩, 七島, 篤志, 2023, Extracellular Volume Fraction Calculated Using Contrast-Enhanced Computed Tomography as a Biomarker of Oxaliplatin-Induced Sinusoidal Obstruction Syndrome: A Preliminary Histopathological Analysis: Hindawi Limited, 1–8 p.
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