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Liver-Expressed Antimicrobial Peptide 2 Is a Hepatokine That Predicts Weight Loss and Complete Remission of Type 2 Diabetes Mellitus after Vertical Sleeve Gastrectomy in Japanese Individuals
http://hdl.handle.net/10458/0002000695
http://hdl.handle.net/10458/0002000695fd787125-7c71-4eae-841e-a2760337ee80
| 名前 / ファイル | ライセンス | アクション |
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2024-08-16 | |||||||||||||||||||
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| タイトル | Liver-Expressed Antimicrobial Peptide 2 Is a Hepatokine That Predicts Weight Loss and Complete Remission of Type 2 Diabetes Mellitus after Vertical Sleeve Gastrectomy in Japanese Individuals | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| キーワード | Liver-expressed antimicrobial peptide 2 | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| キーワード | Ghrelin | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| キーワード | Bariatric surgery | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| キーワード | Obesity | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| キーワード | Diabetes mellitus | |||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||
| アクセス権 | ||||||||||||||||||||
| 著者 |
鍋倉, 弘樹
× 鍋倉, 弘樹× イスラム, エムディ ヌルル× 迫田, 秀之× Yamaguchi, Takashi
× Saiki, Atsuhito
× Nabekura, Taiki
× Oshiro, Takashi
× Tanaka, Yuri
× Murayama, Shinya
× 張, 維東× Tatsuno, Ichiro
× 中里, 雅光 |
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Introduction: Vertical sleeve gastrectomy (VSG) is considered one of the most effective treatments for sustained weight loss and complete remission of type 2 diabetes mellitus (CR-T2DM). Liver-expressed antimicrobial peptide 2 (LEAP2), a ghrelin receptor antagonist peptide, is a metabolic hormone regulated by VSG. However, it is unknown whether LEAP2 can be used to predict the outcomes of VSG. This study aimed to evaluate LEAP2 as a predictive factor for weight loss and CR-T2DM after VSG. Methods: This retrospective study included 39 Japanese participants with obesity who underwent VSG. Serum LEAP2, des-acyl ghrelin (DAG), and other metabolic and anthropometric parameters were studied before and at 12 months after VSG. Receiver operating characteristics (ROC) curve was generated to evaluate predictive score for weight loss with cut-off value of >50 percent excess weight loss. ROC curve was also generated to assess CR-T2DM. Results: Serum LEAP2 levels were significantly higher in participants with body mass index (BMI) 32–50 kg/m2 than in those with normal weight. Participants with BMI >50 kg/m2 had lower serum LEAP2 concentrations than those with BMI 32–50 kg/m2. VSG caused a significant reduction in serum DAG concentrations, but it did not affect serum LEAP2 concentrations in either male or female participants. Preoperative serum LEAP2 concentration of 2.88 pmol/mL was the optimal cutoff value for predicting weight loss after VSG, with sensitivity of 80.0% and specificity of 75.9%. Preoperative serum LEAP2 level higher than 4.67 pmol/mL predicted CR-T2DM after VSG with sensitivity of 100% and specificity of 58.8%. Conclusion: Preoperative serum LEAP2 could predict weight loss and CR-T2DM as outcomes of VSG. |
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| 言語 | en | |||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | Citation: Nabekura H, Islam MN, Sakoda H, Yamaguchi T, Saiki A, Nabekura T, Oshiro T, Tanaka Y, Murayama S, Zhang W, Tatsuno I, Nakazato M. Liver-Expressed Antimicrobial Peptide 2 Is a Hepatokine That Predicts Weight Loss and Complete Remission of Type 2 Diabetes Mellitus after Vertical Sleeve Gastrectomy in Japanese Individuals. Obes Facts. 2023;16(4):392-400. doi: 10.1159/000530733 |
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| 言語 | en | |||||||||||||||||||
| 書誌情報 |
en : Obesity Facts 巻 16, 号 4, p. 392-400, 発行日 2023-04-24 |
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| 出版者 | ||||||||||||||||||||
| 出版者 | S. Karger AG | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 1662-4025 | |||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 1662-4033 | |||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.1159/000530733 | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 権利情報 | © 2023 The Author(s). Published by S. Karger AG, Basel | |||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
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鍋倉, 弘樹 , イスラム, エムディ ヌルル, 迫田, 秀之, Yamaguchi, Takashi, Saiki, Atsuhito, Nabekura, Taiki, Oshiro, Takashi, Tanaka, Yuri, Murayama, Shinya, 張, 維東, Tatsuno, Ichiro, 中里, 雅光, n.d., Liver-Expressed Antimicrobial Peptide 2 Is a Hepatokine That Predicts Weight Loss and Complete Remission of Type 2 Diabetes Mellitus after Vertical Sleeve Gastrectomy in Japanese Individuals: S. Karger AG, 392–400 p.
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