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Efficacy and safety outcomes in Japanese patients with low-risk polycythemia vera treated with ropeginterferon alfa-2b
http://hdl.handle.net/10458/0002000693
http://hdl.handle.net/10458/00020006934073d0e6-06cc-4e5f-b7c3-6f1d01705cfe
| 名前 / ファイル | ライセンス | アクション |
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article (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2024-07-26 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Efficacy and safety outcomes in Japanese patients with low-risk polycythemia vera treated with ropeginterferon alfa-2b | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| キーワード | Hematologic response | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | JAK2 V617F allele burden | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | Low-risk | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| キーワード | Polycythemia vera | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | Ropeginterferon alfa-2b | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | metadata only access | |||||||||||||||||
| 著者 |
下田, 和哉
× 下田, 和哉
WEKO
7997
× Qin, Albert
× Komatsu, Norio
× Kirito, Keita
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| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Polycythemia vera (PV) is a Philadelphia chromosome-negative myeloproliferative neoplasm characterized by clonal erythrocytosis. A phase 2 study reported that ropeginterferon alfa-2b is a well-tolerated and effective treatment for PV in Japanese patients. This post hoc analysis of the phase 2 data further evaluated outcomes in patients at low risk of thrombosis (low-risk PV). Among 20 patients with low-risk PV, 60.0% (12/20) and 85.0% (17/20) achieved < 45% hematocrit by weeks 24 and 52, respectively. The proportion of responders with complete hematologic response (CHR) was 60.0% (12/20) at week 52, and the median time to response was 11.9 months. The mean JAK2 V617F allele burden decreased from 75.8% at baseline to 53.7% at week 52. No patient experienced thrombosis or bleeding episodes. All patients experienced treatment-emergent adverse events (TEAEs) related to ropeginterferon alfa-2b, but no grade ≥ 3 TEAEs or deaths related to ropeginterferon alfa-2b occurred, and no new safety concerns arose. This analysis indicated that ropeginterferon alfa-2b may be an effective treatment option for Japanese patients with low-risk PV. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Citation:Shimoda, K., Qin, A., Komatsu, N. et al. Efficacy and safety outcomes in Japanese patients with low-risk polycythemia vera treated with ropeginterferon alfa-2b. Int J Hematol (2024). https://doi.org/10.1007/s12185-024-03804-1 | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| bibliographic_information |
en : International Journal of Hematology 発行日 2024-07-01 |
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| 出版者 | ||||||||||||||||||
| 出版者 | Springer Science and Business Media LLC | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 0925-5710 | |||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||
| 収録物識別子 | 1865-3774 | |||||||||||||||||
| item_10001_relation_14 | ||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1007/s12185-024-03804-1 | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||
