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Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats
http://hdl.handle.net/10458/0002000510
http://hdl.handle.net/10458/0002000510710d64d5-2b5e-4d20-ba2a-917e9d7d461f
| 名前 / ファイル | ライセンス | アクション |
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article (643 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2024-02-22 | |||||
| タイトル | ||||||
| タイトル | Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Natriuretic peptides | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Noradrenaline | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Cardiac hypertrophy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Rats | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
姜, 丹鳳
× 姜, 丹鳳× Matsuzaki, Minami× 井田, 隆徳× 北村, 和雄× 鶴田, 敏博× 海北, 幸一× 加藤, 丈司 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Excessive activation of the sympathetic nervous system is involved in cardiovascular damage including cardiac hypertrophy. Natriuretic peptides are assumed to exert protective actions for the heart, alleviating hypertrophy and/or fibrosis of the myocardium. In contrast to this assumption, we show in the present study that both atrial and C-type natriuretic peptides (ANP and CNP) potentiate cardiac hypertrophic response to noradrenaline (NA) in rats. Nine-week-old male Wistar rats were continuously infused with subcutaneous 30 micro-g/h NA without or with persistent intravenous administration of either 1.0 micro-g/h ANP or CNP for 14 days. Blood pressure (BP) was recorded under an unrestrained condition by a radiotelemetry system. Cardiac hypertrophic response to NA was evaluated by heart weight/body weight (HW/BW) ratio and microscopic measurement of myocyte size of the left ventricle. Mean BP levels at the light and dark cycles rose by about 20 mmHg following NA infusion for 14 days, with slight increases in HW/BW ratio and ventricular myocyte size. Infusions of ANP and CNP had no significant effects on mean BP in NA-infused rats, while two natriuretic peptides potentiated cardiac hypertrophic response to NA. Cardiac hypertrophy induced by co-administration of NA and ANP was attenuated by treatment with prazosin or atenolol. In summary, both ANP and CNP potentiated cardiac hypertrophic effect of continuously infused NA in rats, suggesting a possible pro-hypertrophic action of natriuretic peptides on the heart. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Jiang D, Matsuzaki M, Ida T, Kitamura K, Tsuruda T, Kaikita K, Kato J. Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats. Peptides. 2023 Aug;166:171035. doi: 10.1016/j.peptides.2023.171035. Epub 2023 May 31. PMID: 37263541. |
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| 言語 | en | |||||
| 書誌情報 |
en : Peptides 巻 166, p. 171035 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 01969781 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.peptides.2023.171035 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2023 The Authors. Published by Elsevier Inc. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
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Cite as
姜, 丹鳳, Matsuzaki, Minami, 井田, 隆徳, 北村, 和雄, 鶴田, 敏博, 海北, 幸一, 加藤, 丈司, n.d., Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats: Elsevier, 171035– p.
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