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Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway
http://hdl.handle.net/10458/0002000497
http://hdl.handle.net/10458/0002000497e91a13de-14f6-4e28-a5ce-500845db4b64
| 名前 / ファイル | ライセンス | アクション |
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article (10.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2024-02-09 | |||||||||||||||||||||
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| タイトル | Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||||
| 著者 |
永井, 琢哉
× 永井, 琢哉× 関本, 朝久× 黒木, 修司× 大田, 智美× 宮﨑, 志保子× 山口, 洋一朗× 田島, 卓也× 帖佐, 悦男× Imasaka, Mai
× Yoshinobu, Kumiko
× Araki, Kimi
× Araki, Masatake
× チヨウジヨウフ, ナランツオツク
WEKO
26967
× 佐藤, 克明× 菱川, 善隆× 舩元, 太郎 |
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| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Bone remodeling is an extraordinarily complex process involving a variety of factors, such as genetic, metabolic, and environmental components. Although genetic factors play a particularly important role, many have not been identified. In this study, we investigated the role of transmembrane 161a (Tmem161a) in bone structure and function using wild-type (WT) and Tmem161a-depleted (Tmem161aGT/GT) mice. Mice femurs were examined by histological, morphological, and bone strength analyses. Osteoblast differentiation and mineral deposition were examined in Tmem161a-overexpressed, -knockdown and -knockout MC3T3-e1 cells. In WT mice, Tmem161a was expressed in osteoblasts of femurs; however, it was depleted in Tmem161aGT/GT mice. Cortical bone mineral density, thickness, and bone strength were significantly increased in Tmem161aGT/GT mice femurs. In MC3T3-e1 cells, decreased expression of alkaline phosphatase (ALP) and Osterix were found in Tmem161a overexpression, and these findings were reversed in Tmem161a-knockdown or -knockout cells. Microarray and western blot analyses revealed upregulation of the P38 MAPK pathway in Tmem161a-knockout cells, which referred as stress-activated protein kinases. ALP and flow cytometry analyses revealed that Tmem161a-knockout cells were resistant to oxidative stress. In summary, Tmem161a is an important regulator of P38 MAPK signaling, and depletion of Tmem161a induces thicker and stronger bones in mice. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||
| 内容記述 | Citation: Nagai T, Sekimoto T, Kurogi S, Ohta T, Miyazaki S, Yamaguchi Y, Tajima T, Chosa E, Imasaka M, Yoshinobu K, Araki K, Araki M, Choijookhuu N, Sato K, Hishikawa Y, Funamoto T. Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway. Sci Rep. 2023 Sep 5;13(1):14639. doi: 10.1038/s41598-023-41837-4. PMID: 37670024; PMCID: PMC10480474. |
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| 言語 | en | |||||||||||||||||||||
| 書誌情報 |
en : Scientific Reports 巻 13, 号 1, p. 14639, 発行日 2023-09-05 |
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| 出版者 | ||||||||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-023-41837-4 | |||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||
| 権利情報 | © The Author(s) 2023 | |||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||
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永井, 琢哉, 関本, 朝久, 黒木, 修司, 大田, 智美, 宮﨑, 志保子, 山口, 洋一朗, 田島, 卓也, 帖佐, 悦男, Imasaka, Mai, Yoshinobu, Kumiko, Araki, Kimi, Araki, Masatake, チヨウジヨウフ, ナランツオツク, 佐藤, 克明, 菱川, 善隆, 舩元, 太郎, 2023, Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway: Springer Nature, 14639– p.
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