| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-02-09 |
| タイトル |
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タイトル |
Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
永井, 琢哉
WEKO
28480
e-Rad_Researcher
60768167
| ja |
永井, 琢哉
宮崎大学
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| ja-Kana |
ナガイ, タクヤ
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| en |
Nagai, Takuya
University of Miyazaki
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Search repository
関本, 朝久
黒木, 修司
WEKO
28474
e-Rad_Researcher
40418843
| ja |
黒木, 修司
宮崎大学
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| ja-Kana |
クロギ, シュウジ
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| en |
Kurogi, Syuji
University of Miyazaki
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Search repository
大田, 智美
WEKO
8099
e-Rad_Researcher
80644096
| ja |
大田, 智美
宮崎大学
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| ja-Kana |
オオタ, トモミ
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| en |
Ohta, Tomomi
Ota, Tomomi
University of Miyazaki
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Search repository
宮﨑, 志保子
山口, 洋一朗
WEKO
34671
e-Rad_Researcher
70822005
| ja |
山口, 洋一朗
宮崎大学
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| ja-Kana |
ヤマグチ, ヨウイチロウ
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| en |
Yamaguchi, Yoichiro
University of Miyazaki
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Search repository
田島, 卓也
WEKO
8097
e-Rad_Researcher
80549056
| ja |
田島, 卓也
宮崎大学
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| ja-Kana |
タジマ, タクヤ
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| en |
Tajima, Takuya
University of Miyazaki
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Search repository
帖佐, 悦男
WEKO
7830
e-Rad_Researcher
00236837
| ja |
帖佐, 悦男
宮崎大学
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| ja-Kana |
チョウサ, エツオ
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| en |
Chosa, Etsuo
University of Miyazaki
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Search repository
Imasaka, Mai
Yoshinobu, Kumiko
Araki, Kimi
Araki, Masatake
チヨウジヨウフ, ナランツオツク
WEKO
26967
e-Rad_Researcher
90640962
| en |
Choijookhuu, Narantsog
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| ja |
チヨウジヨウフ, ナランツオツク
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| ja-Kana |
チヨウジヨウフ, ナランツオツク
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Search repository
佐藤, 克明
WEKO
30111
e-Rad_Researcher
40301147
| ja |
佐藤, 克明
宮崎大学
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| ja-Kana |
サトウ, カツアキ
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| en |
Sato, Katsuaki
University of Miyazaki
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Search repository
菱川, 善隆
WEKO
34189
e-Rad_Researcher
60304276
| ja |
菱川, 善隆
宮崎大学
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| ja-Kana |
ヒシカワ, ヨシタカ
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| en |
Hishikawa, Yoshitaka
University of Miyazaki
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Search repository
舩元, 太郎
WEKO
34184
e-Rad_Researcher
20404452
| ja |
舩元, 太郎
宮崎大学
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| ja-Kana |
フナモト, タロウ
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| en |
Funamoto, Taro
University of Miyazaki
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Search repository
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Bone remodeling is an extraordinarily complex process involving a variety of factors, such as genetic, metabolic, and environmental components. Although genetic factors play a particularly important role, many have not been identified. In this study, we investigated the role of transmembrane 161a (Tmem161a) in bone structure and function using wild-type (WT) and Tmem161a-depleted (Tmem161aGT/GT) mice. Mice femurs were examined by histological, morphological, and bone strength analyses. Osteoblast differentiation and mineral deposition were examined in Tmem161a-overexpressed, -knockdown and -knockout MC3T3-e1 cells. In WT mice, Tmem161a was expressed in osteoblasts of femurs; however, it was depleted in Tmem161aGT/GT mice. Cortical bone mineral density, thickness, and bone strength were significantly increased in Tmem161aGT/GT mice femurs. In MC3T3-e1 cells, decreased expression of alkaline phosphatase (ALP) and Osterix were found in Tmem161a overexpression, and these findings were reversed in Tmem161a-knockdown or -knockout cells. Microarray and western blot analyses revealed upregulation of the P38 MAPK pathway in Tmem161a-knockout cells, which referred as stress-activated protein kinases. ALP and flow cytometry analyses revealed that Tmem161a-knockout cells were resistant to oxidative stress. In summary, Tmem161a is an important regulator of P38 MAPK signaling, and depletion of Tmem161a induces thicker and stronger bones in mice. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Citation:
Nagai T, Sekimoto T, Kurogi S, Ohta T, Miyazaki S, Yamaguchi Y, Tajima T, Chosa E, Imasaka M, Yoshinobu K, Araki K, Araki M, Choijookhuu N, Sato K, Hishikawa Y, Funamoto T. Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway. Sci Rep. 2023 Sep 5;13(1):14639. doi: 10.1038/s41598-023-41837-4. PMID: 37670024; PMCID: PMC10480474. |
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言語 |
en |
| 書誌情報 |
en : Scientific Reports
巻 13,
号 1,
p. 14639,
発行日 2023-09-05
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| 出版者 |
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出版者 |
Springer Nature |
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言語 |
en |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41598-023-41837-4 |
| 権利 |
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権利情報 |
© The Author(s) 2023 |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
article (10.4 MB)
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