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Loss of Tyrosine Kinase 2 Does Not Affect the Severity of Jak2V617F-induced Murine Myeloproliferative Neoplasm
http://hdl.handle.net/10458/0002000456
http://hdl.handle.net/10458/0002000456d8bf8cce-4958-477d-ac36-36d68965249b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2024-01-26 | |||||
| タイトル | ||||||
| タイトル | Loss of Tyrosine Kinase 2 Does Not Affect the Severity of Jak2V617F-induced Murine Myeloproliferative Neoplasm | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Myeloproliferative neoplasms | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | JAK2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | TYK2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | animal models | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | JAK2 inhibitors | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
山路, 卓巳
× 山路, 卓巳× 幣, 光太郎× 亀田, 拓郎× 関根, 雅明× 上運天, 綾子× 日髙, 智徳× 久冨木, 庸子× 下田, 晴子× 安倍, 弘生× 三池, 忠× 岩切, 久芳× 田原, 良博× 末田, 光恵× 山本, 章二朗× 蓮池, 悟× 永田, 賢治× 下田, 和哉 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/Aim: In myeloproliferative neoplasms (MPN), Janus kinase 2 (JAK2) is activated by mutations including JAK2V617F (JAK2VF). It is unclear whether JAK kinases [i.e. JAK1, JAK2, JAK3, or tyrosine kinase 2 (TYK2)] other than JAK2 have cooperative actions such as enhancement or suppression of JAK2. If other kinases enhance activation, therapies that co-target them could have a therapeutic efficacy. We examined the role of TYK2 in Jak2VF-induced murine MPN. Materials and Methods: We crossed Jak2VF transgenic mice and Tyk2-knockout (Tyk2KO) mice to generate Jak2VF/Tyk2KO mice. The disease severity and treatment effect with a JAK2 inhibitor was compared between Jak2VF and Jak2VF/Tyk2KO mice. Results: Both types of mice developed MPN, and there were no differences in peripheral blood counts, spleen weight, or survival period. Upon JAK2 inhibitor therapy, both types of mice had equally improved leukocytosis and splenomegaly. Conclusion: TYK2 does not have cooperative effects with JAK2VF upon MPN onset nor in the presence of a JAK2 inhibitor. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Yamaji T, Shide K, Kameda T, Sekine M, Kamiunten A, Hidaka T, Kubuki Y, Shimoda H, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Shimoda K. Loss of Tyrosine Kinase 2 Does Not Affect the Severity of Jak2V617F-induced Murine Myeloproliferative Neoplasm. Anticancer Res. 2017 Jul;37(7):3841-3847. doi: 10.21873/anticanres.11763. PMID: 28668884. |
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| 言語 | en | |||||
| 書誌情報 |
en : Anticancer Research 巻 37, 号 7, p. 3841-3847 |
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| 出版者 | ||||||
| 出版者 | Anticancer Research | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 02507005 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.21873/anticanres.11763 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
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山路, 卓巳, 幣, 光太郎, 亀田, 拓郎, 関根, 雅明, 上運天, 綾子, 日髙, 智徳, 久冨木, 庸子, 下田, 晴子, 安倍, 弘生, 三池, 忠, 岩切, 久芳, 田原, 良博, 末田, 光恵, 山本, 章二朗, 蓮池, 悟, 永田, 賢治, 下田, 和哉, n.d., Loss of Tyrosine Kinase 2 Does Not Affect the Severity of Jak2V617F-induced Murine Myeloproliferative Neoplasm: Anticancer Research, 3841–3847 p.
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