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Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential
http://hdl.handle.net/10458/0002000454
http://hdl.handle.net/10458/0002000454bd6009bd-f88f-4f81-9207-d1c5a197fb04
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2024-01-26 | |||||
| タイトル | ||||||
| タイトル | Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
田村, 知丈
× 田村, 知丈× Ichikawa, Tomonaga× Nakahata, Shingo× Kondo, Yudai× Tagawa, Yuri× 山本, 晃士× Nagai, Kentaro× 馬場, 崇× 山口, 良二× Futakuchi, Mitsuru× 山下, 善弘× 森下, 和広 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Loss of the tumor suppressor NDRG2 has been implicated in the development of oral squamous cell carcinoma (OSCC), acting by modulating PI3K/AKT-mediated dephosphorylation of PTEN at S380/S382/T383 (STT). Here, we show that the majority of OSCC tumors with lymph node metastasis, a major prognostic factor, exhibit high levels of phosphorylated AKT-S473 and PTEN-STT and low levels of NDRG2 expression. In Ndrg2-deficient mice, which develop a wide range of tumors, we developed a model of OSCC by treatment with the tobacco surrogate 4-nitroquinoline-1-oxide (4-NQO). In this model, both the number and size of OSCC tumors were increased significantly by Ndrg2 deficiency, which also increased invasion of cervical lymph nodes. 4-NQO treatment of human OSCC cell lines exhibiting low NDRG2 expression induced epithelial–mesenchymal transition via activation of NF-κB signaling. Conversely, ectopic expression of NDRG2 reversed the EMT phenotype and inhibited NF-κB signaling via suppression of PTEN-STT and AKT-S473 phosphorylation. Our results show how NDRG2 expression serves as a critical determinant of the invasive and metastatic capacity of OSCC. Cancer Res; 77(9); 2363–74. ©2017 AACR. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Tamura T, Ichikawa T, Nakahata S, Kondo Y, Tagawa Y, Yamamoto K, Nagai K, Baba T, Yamaguchi R, Futakuchi M, Yamashita Y, Morishita K. Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential. Cancer Res. 2017 May 1;77(9):2363-2374. doi: 10.1158/0008-5472.CAN-16-2114. Epub 2017 Feb 16. PMID: 28209617. |
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| 言語 | en | |||||
| 書誌情報 |
en : Cancer Research 巻 77, 号 9, p. 2363-2374, 発行日 2017-04-30 |
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| 出版者 | ||||||
| 出版者 | American Association for Cancer Research | |||||
| 言語 | en | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0008-5472 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1158/0008-5472.can-16-2114 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
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田村, 知丈, Ichikawa, Tomonaga, Nakahata, Shingo, Kondo, Yudai, Tagawa, Yuri, 山本, 晃士, Nagai, Kentaro, 馬場, 崇, 山口, 良二, Futakuchi, Mitsuru, 山下, 善弘, 森下, 和広, 2017, Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential: American Association for Cancer Research, 2363–2374 p.
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