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Antiparallel RNA G-quadruplex Formed by Human Telomere RNA Containing 8-Bromoguanosine
http://hdl.handle.net/10458/0002000447
http://hdl.handle.net/10458/00020004475902762d-bc43-40e2-aab3-5eb599852455
| 名前 / ファイル | ライセンス | アクション |
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article (2.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2024-01-25 | |||||
| タイトル | ||||||
| タイトル | Antiparallel RNA G-quadruplex Formed by Human Telomere RNA Containing 8-Bromoguanosine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
肖, 潮達
× 肖, 潮達× 石塚, 匠× 徐, 岩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this study, by combining nuclear magnetic resonance (NMR), circular dichroism (CD), liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS), and gel electrophoresis, we report an unusual topological structure of the RNA G-quadruplex motif formed by human telomere RNA r(UAGGGU) containing 8-bromoguanosine. Results showed that the RNA sequence formed an antiparallel tetramolecular G-quadruplex, in which each pair of diagonal strands run in opposite directions. Furthermore, guanosines were observed both in syn- and anti-conformations. In addition, two of these G-quadruplex subunits were found to be stacking on top of each other, forming a dimeric RNA G-quadruplex. Our findings provide a new insight into the behavior of RNA G-quadruplex structures. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Xiao CD, Ishizuka T, Xu Y. Antiparallel RNA G-quadruplex Formed by Human Telomere RNA Containing 8-Bromoguanosine. Sci Rep. 2017 Jul 27;7(1):6695. doi: 10.1038/s41598-017-07050-w. PMID: 28751647; PMCID: PMC5532209. |
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| 言語 | en | |||||
| 書誌情報 |
en : Scientific Reports 巻 7, 号 1, p. 6695, 発行日 2017-07-27 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| 言語 | en | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s41598-017-07050-w | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © The Author(s) 2017 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
