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Unusual Topological RNA Architecture with an Eight-Stranded Helical Fragment Containing A-, G-, and U-Tetrads
http://hdl.handle.net/10458/0002000446
http://hdl.handle.net/10458/000200044602a7c508-0799-4b3c-8929-e08c03f7e770
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2024-01-25 | |||||
| タイトル | ||||||
| タイトル | Unusual Topological RNA Architecture with an Eight-Stranded Helical Fragment Containing A-, G-, and U-Tetrads | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
肖, 潮達
× 肖, 潮達× 石塚, 匠× Zhu, Xiao-Qing× Li, Yue× Sugiyama, Hiroshi× 徐, 岩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Human telomeric RNA performs various cellular functions such as telomere length regulation, heterochromatin formation, and chromosome end protection. Using a combination of nuclear magnetic resonance, circular dichroism, and gel electrophoresis, we observed an unusual topological structure formed by human telomere RNA r(GUUAGGGU). Our results showed that every set of four strands formed a parallel G-quadruplex as symmetry-related units containing four G-tetrads, two U-tetrads, and one A-tetrad. An eight-stranded helical fragment containing A-, G-, and U-tetrads provided a central intercalated scaffold that connected two G-quadruplex units in an alternating antiparallel arrangement, giving rise to a novel RNA architecture. This higher order RNA structure is so stable that it would be surprising if similar structures do not occur in nature. Our findings provide a new insight into the behavior of human telomeric RNA molecules. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Xiao CD, Ishizuka T, Zhu XQ, Li Y, Sugiyama H, Xu Y. Unusual Topological RNA Architecture with an Eight-Stranded Helical Fragment Containing A-, G-, and U-Tetrads. J Am Chem Soc. 2017 Feb 22;139(7):2565-2568. doi: 10.1021/jacs.6b12274. Epub 2017 Feb 13. PMID: 28177615. |
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| 言語 | en | |||||
| 書誌情報 |
en : Journal of the American Chemical Society 巻 139, 号 7, p. 2565-2568, 発行日 2017-02-08 |
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| 出版者 | ||||||
| 出版者 | ACS Publications | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0002-7863 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1021/jacs.6b12274 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
