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Structure-Dependent Binding of hnRNPA1 to Telomere RNA
http://hdl.handle.net/10458/0002000443
http://hdl.handle.net/10458/0002000443b9e95781-d984-46f9-9f9c-d496bd156ac7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2024-01-25 | |||||
| タイトル | ||||||
| タイトル | Structure-Dependent Binding of hnRNPA1 to Telomere RNA | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
劉, 暁
× 劉, 暁× 石塚, 匠× 鮑, 宏亮× 和田, 啓× Takeda, Yuma× Iida, Keisuke× Nagasawa, Kazuo× Yang, Danzhou× 徐, 岩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Telomeric repeat-containing RNA is a new noncoding RNA molecule that performs various biofunctions. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein involved in the telomere maintenance machinery. To date, little is known about how hnRNPA1 binds to telomeric RNA. In this study, we investigated the binding affinity and recognition mechanism of telomere RNA with the RNA recognition motif of hnRNPA1. Using the photochemical cross-linking method, we showed that the telomere RNA G-quadruplex with loops is important in the interaction of telomere RNA with hnRNPA1. Using small-molecule probes, we directly visualized the complex formed by the telomere RNA G-quadruplex and hnRNPA1 in vitro and in live cells. The results suggested that the structure-dependent binding of hnRNPA1 to telomere RNA regulates the telomere function. Therefore, our study provides new insights into the interactions between the RNA G-quadruplex and proteins at the telomere. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Liu X, Ishizuka T, Bao HL, Wada K, Takeda Y, Iida K, Nagasawa K, Yang D, Xu Y. Structure-Dependent Binding of hnRNPA1 to Telomere RNA. J Am Chem Soc. 2017 Jun 7;139(22):7533-7539. doi: 10.1021/jacs.7b01599. Epub 2017 May 24. PMID: 28510424; PMCID: PMC5977995. |
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| 言語 | en | |||||
| 書誌情報 |
en : Journal of the American Chemical Society 巻 139, 号 22, p. 7533-7539, 発行日 2017-05-16 |
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| 出版者 | ||||||
| 出版者 | ACS Publications | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0002-7863 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1021/jacs.7b01599 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
