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2′-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA
http://hdl.handle.net/10458/0002000436
http://hdl.handle.net/10458/0002000436128d7200-13da-4529-a03a-f363f61a176d
名前 / ファイル | ライセンス | アクション |
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article (3.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2024-01-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 2′-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | Z-RNA structure | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | synthesis of oligonucleotide | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | NMR | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | circular dichroism | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Balasubramaniyam, Thananjeyan
× Balasubramaniyam, Thananjeyan× 石塚, 匠× 肖, 潮達× 鮑, 宏亮× 徐, 岩 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In contrast to Z-DNA that was stabilized and well-studied for its structure by chemical approaches, the stabilization and structural study of Z-RNA remains a challenge. In this study, we developed a Z-form RNA stabilizer m8Gm, and demonstrated that incorporation of m8Gm into RNA can markedly stabilize the Z-RNA at low salt conditions. Using the m8Gm-contained Z-RNA, we determined the structure of Z-RNA and investigated the interaction of protein and Z-RNA. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | citeation: Balasubramaniyam T, Ishizuka T, Xiao CD, Bao HL, Xu Y. 2'-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA. Molecules. 2018 Oct 9;23(10):2572. doi: 10.3390/molecules23102572. PMID: 30304782; PMCID: PMC6222775. |
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言語 | en | |||||
書誌情報 |
en : Molecules 巻 23, 号 10, p. 2572, 発行日 2018-10-09 |
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DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3390/molecules23102572 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2018 by the authors | |||||
著者版フラグ | ||||||
出版タイプ | VoR |