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Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB
http://hdl.handle.net/10458/0002000434
http://hdl.handle.net/10458/0002000434eb2822ec-3611-4072-994c-605324e88d2d
| 名前 / ファイル | ライセンス | アクション |
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article (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2024-01-15 | |||||||||
| タイトル | ||||||||||
| タイトル | Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB | |||||||||
| 言語 | en | |||||||||
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| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
サルカル, ビードン チャンドラ
× サルカル, ビードン チャンドラ× Nishikata, Ichiro× Nakahata, Shingo× Ichikawa, Tomonaga× Shiraga, Toshiyuki× サハ, ハシ ラニ× Fujii, Masahiro
× Tanaka, Yuetsu
× 下田, 和哉× 森下, 和広 |
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Cell adhesion molecule 1 (CADM1), a member of the immunoglobulin superfamily, is identified as a novel cell surface marker for human T-cell leukemia virus (HTLV-1)-infected T cells. Adult T-cell leukemia/lymphoma (ATLL) is developed in HTLV-1-infected T-cells after a long infection period. To examine the mechanism of CADM1 overexpression in ATLL, we first identified that CADM1 is transcriptionally up-regulated by a transcriptional enhancer element through NF-κB signaling pathway. In HTLV-1-infected T-cells, CADM1 expression is dependent on HTLV-1/Tax through activation of canonical and non-canonical NF-κB; however, in ATLL cells with frequent loss of Tax expression, the activation of canonical NF-κB only enhances the CADM1 expression. Along with active mutations in signaling molecules under T-cell recepor (TCR) signaling, degradation of p47, a negative regulator of NF-κB, was essential for activation of canonical NF-κB through stabilization of NEMO (NF-κB essential modulator). The mechanism of p47 degradation is primarily dependent on activation of lysosomal-autophagy and the autophagy is activated in most of the HTLV-infected and ATLL cells, suggesting that the p47 degradation may be a first key molecular event during HTLV-1 infection to T-cells as a connector of two important signaling pathways, NF-κB and autophagy. | |||||||||
| 言語 | en | |||||||||
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| 内容記述タイプ | Other | |||||||||
| 内容記述 | citeation: Sarkar B, Nishikata I, Nakahata S, Ichikawa T, Shiraga T, Saha HR, Fujii M, Tanaka Y, Shimoda K, Morishita K. Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB. Sci Rep. 2019 Mar 5;9(1):3491. doi: 10.1038/s41598-019-39424-7. PMID: 30837480; PMCID: PMC6400899. |
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| 言語 | en | |||||||||
| 書誌情報 |
en : Scientific Reports 巻 9, 号 1, p. 3491, 発行日 2019-03-05 |
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| 出版者 | ||||||||||
| 出版者 | Springer Nature | |||||||||
| 言語 | en | |||||||||
| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-019-39424-7 | |||||||||
| 権利 | ||||||||||
| 言語 | en | |||||||||
| 権利情報 | © The Author(s) 2019 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
