WEKO3
アイテム
Estrogen Accelerates Cell Proliferation through Estrogen Receptor α during Rat Liver Regeneration after Partial Hepatectomy
http://hdl.handle.net/10458/0002000414
http://hdl.handle.net/10458/0002000414853aad82-d5ef-49a1-b0a7-d2664fa5da31
| 名前 / ファイル | ライセンス | アクション |
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article (1.8 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2023-12-22 | |||||||||||||||||||||||
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| タイトル | Estrogen Accelerates Cell Proliferation through Estrogen Receptor α during Rat Liver Regeneration after Partial Hepatectomy | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| キーワード | estrogen | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | estrogen receptor α | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | liver regeneration | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | partial hepatectomy | |||||||||||||||||||||||
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| 言語 | en | |||||||||||||||||||||||
| キーワード | cell proliferation | |||||||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 著者 |
Batmunkh, Baatarsuren
× Batmunkh, Baatarsuren× チヨウジヨウフ, ナランツオツク
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26967
× スリソワナ, ナパリ× Byambatsogt, Uugantsetseg× ピュー , シン ウー
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27789
× Mohmand, Noor Ali× 山口, 優也× 菱川, 善隆
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34189
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| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | Although estrogen is implicated in the regulation of cell growth and differentiation in many organs, the exact mechanism for liver regeneration is not completely understood. We investigated the effect of estrogen on liver regeneration in male and female Wistar rats after 70% partial hepatectomy (PHx) and performed immunohistochemistry, western blotting and Southwestern histochemistry. 17β-estradiol (E2) and ICI 182,780 were injected into male rats on the day before PHx. The proliferating cell nuclear antigen (PCNA) labeling index reached a maximum at 48 hr after PHx in males, and at 36 hr in females and E2-treated male rats. Estrogen receptor α (ERα) was expressed in zones 1 and 2 in male rats, but was found in all zones in female rats. Interestingly, ERα was not detected at 6–12 hr after PHx but was found at 24–168 hr in male rats. However, ERα expression was found at all sampling time-points in female and E2-treated male rats. The activity of estrogen responsive element binding proteins was detected from 12 hr after PHx in male rats but was found from 6 hr in female and E2-treated male rats. ERα was co-expressed with PCNA during liver regeneration. These results indicate that estrogen may play an important role in liver regeneration through ERα. | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | Citation: Batmunkh B, Choijookhuu N, Srisowanna N, Byambatsogt U, Synn Oo P, Noor Ali M, Yamaguchi Y, Hishikawa Y. Estrogen Accelerates Cell Proliferation through Estrogen Receptor α during Rat Liver Regeneration after Partial Hepatectomy. Acta Histochem Cytochem. 2017 Feb 28;50(1):39-48. doi: 10.1267/ahc.17003. Epub 2017 Feb 25. PMID: 28386149; PMCID: PMC5374102. |
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| 言語 | en | |||||||||||||||||||||||
| 書誌情報 |
en : Acta Histochemica et Cytochemica 巻 50, 号 1, p. 39-48, 発行日 2017-02-28 |
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| 出版者 | Japan Society of Histochemistry and Cytochemistry | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 0044-5991 | |||||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1267/ahc.17003 | |||||||||||||||||||||||
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| 権利情報 | © 2017 The Japan Society of Histochemistry and Cytochemistry | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||
