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Novel Porcine Epidemic Diarrhea Virus (PEDV) Variants with Large Deletions in the Spike (S) Gene Coexist with PEDV Strains Possessing an Intact S Gene in Domestic Pigs in Japan: A New Disease Situation
http://hdl.handle.net/10458/0002000400
http://hdl.handle.net/10458/00020004006923e5c3-5932-4c38-a0f9-387750183f66
| 名前 / ファイル | ライセンス | アクション |
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article (911 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-12-21 | |||||
| タイトル | ||||||
| タイトル | Novel Porcine Epidemic Diarrhea Virus (PEDV) Variants with Large Deletions in the Spike (S) Gene Coexist with PEDV Strains Possessing an Intact S Gene in Domestic Pigs in Japan: A New Disease Situation | |||||
| 言語 | en | |||||
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| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Nguyen, Van Diep
× Nguyen, Van Diep× 乗峰, 潤三× 末吉, 益雄× ラン, グエン ティ× 山口, 良二 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Since late 2013, after an absence of seven years, outbreaks of porcine epidemic diarrhea virus (PEDV) infection have reemerged and swept rapidly across Japan, resulting in significant economic losses. In this study, we report the emergence, mixed infection, and genetic characterization of 15 novel field PEDV variants with large genomic deletions. The sizes of deletion varied between 582 nt (194 aa) and 648 nt (216 aa) at positions 28–714 (10–238) on the S gene (protein). Among 17 PEDV samples isolated from individual pigs, all of them contained at least two distinct genotypes with large genomic deletions, and 94.1% of them were found to consist of strains with an intact S gene. These variants were found in eight primary and nine recurrent outbreaks, and they might be associated with persistent PEDV infection in the farms. Full-length S and ORF3 genes of eight variants derived from 2 samples were characterized. This is the first report of mixed infections caused by various genotypes of PEDV and would be important for the studies of viral isolation, pathogenesis, and molecular epidemiology of the disease. | |||||
| 言語 | en | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | citation: Diep NV, Norimine J, Sueyoshi M, Lan NT, Yamaguchi R. Novel Porcine Epidemic Diarrhea Virus (PEDV) Variants with Large Deletions in the Spike (S) Gene Coexist with PEDV Strains Possessing an Intact S Gene in Domestic Pigs in Japan: A New Disease Situation. PLoS One. 2017 Jan 17;12(1):e0170126. doi: 10.1371/journal.pone.0170126. PMID: 28095455; PMCID: PMC5241010. |
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| 言語 | en | |||||
| 書誌情報 |
en : PLOS ONE 巻 12, 号 1, p. e0170126, 発行日 2017-01-17 |
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| 出版者 | PLOS | |||||
| 言語 | en | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0170126 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2017 Diep et al | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
