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Role of the neural pathway from hindbrain to hypothalamus in the regulation of energy homeostasis in rats
http://hdl.handle.net/10458/0002000395
http://hdl.handle.net/10458/00020003954118ed56-9f78-4a9e-ade5-a1aa2e8c41a5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-12-20 | |||||
| タイトル | ||||||
| タイトル | Role of the neural pathway from hindbrain to hypothalamus in the regulation of energy homeostasis in rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Food intake | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Leptin signaling | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Energy homeostasis | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
宇藤山, 麻衣子
× 宇藤山, 麻衣子× 秋枝, さやか× Koda, Shuichi× 布井, 博幸× 伊達, 紫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recent evidence suggests that neural pathways from the hindbrain to the hypothalamus are important for informing the hypothalamus of the body’s condition with regard to energy metabolism. Here we examined energy metabolism in rats with transections of the midbrain that severed the neural pathway from the hindbrain to the hypothalamus, and then investigated the levels of various molecules associated with control of energy metabolism in these rats. Food intake and body weight were higher in the midbrain-transected rats than in sham-operated rats. In addition, the midbrain-transected rats showed insulin resistance and hyperleptinemia. Furthermore, the hypothalamic mRNA levels of anorectic proopiomelanocortin and cocaine- and amphetamine-related transcript were significantly lower in midbrain-transected rats than in sham-operated rats. Our findings elucidate the mechanisms of food intake and energy balance from the perspective of multifactorial regulatory systems that underlie functions such as neurohormonal integration. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | citation: Utoyama M, Akieda-Asai S, Koda S, Nunoi H, Date Y. Role of the neural pathway from hindbrain to hypothalamus in the regulation of energy homeostasis in rats. Neurosci Lett. 2016 Feb 12;614:83-8. doi: 10.1016/j.neulet.2016.01.005. Epub 2016 Jan 8. PMID: 26773865. |
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| 書誌情報 |
en : Neuroscience Letters 巻 614, p. 83-88, 発行日 2016-02-12 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03043940 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.neulet.2016.01.005 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2016 Elsevier Ireland Ltd. All rights reserved. | |||||
