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Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation
http://hdl.handle.net/10458/0002000390
http://hdl.handle.net/10458/000200039065e1c4bf-55ee-4331-8c9a-c77ad853e03b
| 名前 / ファイル | ライセンス | アクション |
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article (552 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-12-19 | |||||
| タイトル | ||||||
| タイトル | Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | ghrelin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | diet-induced obesity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | nodose ganglion | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | vagus nerve | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | inflammation | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Naznin, Farhana
× Naznin, Farhana× 十枝内, 厚次× Waise, T.M. Zaved× NamKoong, Cherl× Moin, Abu Saleh Md.× 迫田, 秀之× 中里, 雅光 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ghrelin, a stomach-derived orexigenic peptide, transmits starvation signals to the hypothalamus via the vagus afferent nerve. Peripheral administration of ghrelin does not induce food intake in high fat diet (HFD)-induced obese mice. We investigated whether this ghrelin resistance was caused by dysfunction of the vagus afferent pathway. Administration (s.c.) of ghrelin did not induce food intake, suppression of oxygen consumption, electrical activity of the vagal afferent nerve, phosphorylation of ERK2 and AMP-activated protein kinase alpha in the nodose ganglion, or Fos expression in hypothalamic arcuate nucleus of mice fed a HFD for 12 weeks. Administration of anti-ghrelin IgG did not induce suppression of food intake in HFD-fed mice. Expression levels of ghrelin receptor mRNA in the nodose ganglion and hypothalamus of HFD-fed mice were reduced. Inflammatory responses, including upregulation of macrophage/microglia markers and inflammatory cytokines, occurred in the nodose ganglion and hypothalamus of HFD-fed mice. A HFD blunted ghrelin signaling in the nodose ganglion via a mechanism involving in situ activation of inflammation. These results indicate that ghrelin resistance in the obese state may be caused by dysregulation of ghrelin signaling via the vagal afferent. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Naznin F, Toshinai K, Waise TM, NamKoong C, Md Moin AS, Sakoda H, Nakazato M. Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation. J Endocrinol. 2015 Jul;226(1):81-92. doi: 10.1530/JOE-15-0139. Epub 2015 May 27. PMID: 26016745; PMCID: PMC4485401. |
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| 言語 | en | |||||
| 書誌情報 |
en : Journal of Endocrinology 巻 226, 号 1, p. 81-92 |
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| 出版者 | ||||||
| 出版者 | Bioscientifica | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-0795 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1530/JOE-15-0139 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2015 The authors 2015 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
