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Changes in TRPV1 Receptor, CGRP, and BDNF Expression in Rat Dorsal Root Ganglion with Resiniferatoxin-Induced Neuropathic Pain: Modulation by Pulsed Radiofrequency Applied to the Sciatic Nerve
http://hdl.handle.net/10458/0002000361
http://hdl.handle.net/10458/00020003612d24fa7b-8cf0-4722-a691-36c53c2bcf51
| 名前 / ファイル | ライセンス | アクション |
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article (264 KB)
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利用は著作権の範囲内に限られます
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2023-12-08 | |||||||
| タイトル | ||||||||
| タイトル | Changes in TRPV1 Receptor, CGRP, and BDNF Expression in Rat Dorsal Root Ganglion with Resiniferatoxin-Induced Neuropathic Pain: Modulation by Pulsed Radiofrequency Applied to the Sciatic Nerve | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | pulsed radiofrequency | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | resiniferatoxin | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | transient receptor potential vanilloid subtype-1 (TRPV1) | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | calcitonin gene-related peptide (CGRP) | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | brain-derived neurotrophic factor (BDNF) | |||||||
| 資源タイプ | ||||||||
| 資源タイプ | journal article | |||||||
| 著者 |
越田, 智広
× 越田, 智広× 丸田, 豊明× Tanaka, Nobuhiko
× 日髙, 康太郎× 黒木, 未央× Nemoto, Takayuki× 柳田, 俊彦× 武谷, 立× 恒吉, 勇男 |
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Pulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the dorsal root ganglia by western blotting. Expressions of TRPV1 and CGRP were significantly lower in the contralateral (RTX-treated, PRF-untreated) tissue than in control rats (p<0.0001 and p<0.0001, respectively) and the ipsilateral tissues (p<0.0001 and p<0.0001, respectively). BDNF levels were significantly higher in the contralateral tissues than in the control rats (p<0.0001) and the ipsilateral tissues (p<0.0001). These results suggest that, while TRPV1 and CGRP are decreased by RTX-induced neuronal damage, increased BDNF levels result in pain development. PRF may promote recovery from neuronal damage with concomitant restoration of TRPV1 and CGRP, and exert its analgesic effect by reversing BDNF increase. Further research is required to understand the role of TRPV1 and CGRP restoration in improving mechanical allodynia. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Citation: Koshida T, Maruta T, Tanaka N, Hidaka K, Kurogi M, Nemoto T, Yanagita T, Takeya R, Tsuneyoshi I. Changes in TRPV1 Receptor, CGRP, and BDNF Expression in Rat Dorsal Root Ganglion with Resiniferatoxin-Induced Neuropathic Pain: Modulation by Pulsed Radiofrequency Applied to the Sciatic Nerve. Acta Med Okayama. 2023 Aug;77(4):359-364. doi: 10.18926/AMO/65741. PMID: 37635135. |
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| 言語 | en | |||||||
| 書誌情報 |
en : Acta Medica Okayama 巻 77, 号 4, p. 359-364, 発行日 2023 |
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| 出版者 | ||||||||
| 出版者 | Okayama University Medical School | |||||||
| 言語 | en | |||||||
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| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 0386-300X | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.18926/AMO/65741 | |||||||
| 権利 | ||||||||
| 言語 | en | |||||||
| 権利情報 | Ⓒ 2023 by Okayama University Medical School | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
