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HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles
http://hdl.handle.net/10458/0002000354
http://hdl.handle.net/10458/0002000354c9a3c39e-03de-4169-bbd5-67aec5a793ed
| 名前 / ファイル | ライセンス | アクション |
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本文 (2.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2023-11-28 | |||||||||||||||||
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| タイトル | HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
李, 徳哲
× 李, 徳哲× 谷口, 昇× 佐藤, 克明× チヨウジヨウフ, ナランツオツク
WEKO
26967
× 菱川, 善隆× 片岡, 寛章× Morinaga, Hidetaka
× Lotz, Martin
× 帖佐, 悦男 |
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| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Although various surgical procedures have been developed for chronic rotator cuff tear repair, the re-tear rate remains high with severe fat infiltration. However, little is known about the molecular regulation of this process. Mesenchymal stem cells (MSCs) in the intra-muscular space are origin of ectopic fat cells in skeletal muscle. We have previously shown that high-mobility group box 2 (HMGB2), which is a nuclear protein commonly associated with mesenchymal differentiation, is involved in the early articular cartilage degeneration. In this study, we addressed the role of HMGB2 in adipogenesis of MSCs and fat infiltration into skeletal muscles. HMGB2 was highly expressed in undifferentiated MSCs and co-localized with platelet-derived growth factor receptor α (PDGFRA) known as an MSC-specific marker, while their expressions were decreased during adipocytic differentiation. Under the deficiency of HMGB2, the expressions of adipogenesis-related molecules were reduced, and adipogenic differentiation is substantially impaired in MSCs. Moreover, HMGB2+ cells were generated in the muscle belly of rat supraspinatus muscles after rotator cuff transection, and some of these cells expressed PDGFRA in intra-muscular spaces. Thus, our findings suggest that the enhance expression of HMGB2 induces the adipogenesis of MSCs and the fat infiltration into skeletal muscles through the cascade of HMGB2-PDGFRA. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Citation: Lee D, Taniguchi N, Sato K, Choijookhuu N, Hishikawa Y, Kataoka H, Morinaga H, Lotz M, Chosa E. HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles. Sci Rep. 2018 Jun 25;8(1):9601. doi: 10.1038/s41598-018-28023-7. Erratum in: Sci Rep. 2020 Mar 10;10(1):4647. PMID: 29942000; PMCID: PMC6018498. |
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| 言語 | en | |||||||||||||||||
| 書誌情報 |
en : Scientific Reports 巻 8, 号 1, p. 9601 (2018), 発行日 2018-06-25 |
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| 出版者 | ||||||||||||||||||
| 出版者 | SpringerNature | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-018-28023-7 | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | © The Author(s) 2018 | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
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李, 徳哲, 谷口, 昇, 佐藤, 克明, チヨウジヨウフ, ナランツオツク, 菱川, 善隆, 片岡, 寛章, Morinaga, Hidetaka, Lotz, Martin, 帖佐, 悦男, 2018, HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles: SpringerNature, 9601 (2018)– p.
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