ログイン
言語:

WEKO3

  • トップ
  • ランキング
To

Field does not validate



インデックスリンク

インデックスツリー

  • RootNode

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 医学獣医学総合研究科
  1. 医学獣医学総合研究科
  2. 医学獣医学総合研究科学術雑誌掲載論文

Extracellular signal-regulated kinase phosphorylation enhancement and NaV1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic pain: The efficacy and mechanism of pulsed radiofrequency therapy

http://hdl.handle.net/10458/0002000271
http://hdl.handle.net/10458/0002000271
1acbd320-038d-4f9b-beaa-a8994c58d197
名前 / ファイル ライセンス アクション
日髙論文.pdf 本文 (1.5 MB)
license.icon
Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-11-01
タイトル
タイトル Extracellular signal-regulated kinase phosphorylation enhancement and NaV1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic pain: The efficacy and mechanism of pulsed radiofrequency therapy
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 日髙, 康太郎

× 日髙, 康太郎

WEKO 34788
e-Rad_Researcher 20750392

ja 日髙, 康太郎

ja-Kana ヒダカ, コウタロウ

en Hidaka, Kotaro


Search repository
丸田, 豊明

× 丸田, 豊明

WEKO 34465
e-Rad_Researcher 20363591

ja 丸田, 豊明

ja-Kana マルタ, トヨアキ

en Maruta, Toyoaki


Search repository
越田, 智広

× 越田, 智広

WEKO 34811
e-Rad_Researcher 20441842

ja 越田, 智広

ja-Kana コシダ, トモヒロ

en Koshida, Tomohiro


Search repository
黒木, 未央

× 黒木, 未央

WEKO 34812

en Kurogi, Mio

ja 黒木, 未央

ja-Kana クロギ, ミオ


Search repository
鹿毛, 陽子

× 鹿毛, 陽子

WEKO 34813
e-Rad_Researcher 30776688

ja 鹿毛, 陽子

ja-Kana カゲ, ヨウコ

en Kage, Yohko


Search repository
Kouroki Satoshi

× Kouroki Satoshi

en Kouroki Satoshi

Search repository
白坂, 哲朗

× 白坂, 哲朗

WEKO 16322
e-Rad 00274788

en Shirasaka, Tetsuro

ja 白坂, 哲朗

ja-Kana シラサカ, テツロウ


Search repository
武谷, 立

× 武谷, 立

WEKO 34481
e-Rad_Researcher 50335981

ja 武谷, 立

ja-Kana タケヤ, リュウ

en Takeya, Ryu


Search repository
恒吉, 勇男

× 恒吉, 勇男

WEKO 8080
e-Rad_Researcher 90301390

ja 恒吉, 勇男

ja-Kana ツネヨシ, イサオ

en Tsuneyoshi, Isao


Search repository
抄録
内容記述タイプ Abstract
内容記述 Pulsed radiofrequency (PRF) therapy is one of the most common treatment options for neuropathic pain, albeit the underlying mechanism has not been hitherto elucidated. In this study, we investigated the efficacy and mechanism of PRF therapy on resiniferatoxin (RTX)-induced mechanical allodynia, which has been used as a model of postherpetic neuralgia (PHN). Adult male rats were intraperitoneally injected with a vehicle or RTX. Furthermore, PRF current was applied on a unilateral sciatic nerve in all RTX-treated rats. On both ipsilateral and contralateral sides, the paw mechanical withdrawal thresholds were examined and L4-6 dorsal root ganglia (DRG) were harvested. In the DRG of rats with RTX-induced mechanical allodynia, NaV1.7, a voltage-gated Na+ channel, was upregulated following the enhancement of extracellular signal-regulated kinase phosphorylation. Early PRF therapy, which was applied 1 week after RTX exposure, suppressed this NaV1.7 upregulation and showed an anti-allodynic effect; however, late PRF therapy, which was applied after 5 weeks of RTX exposure, failed to inhibit allodynia. Interestingly, late PRF therapy became effective after daily tramadol administration for 7 days, starting from 2 weeks after RTX exposure. Both early PRF therapy and late PRF therapy combined with early tramadol treatment suppressed NaV1.7 upregulation in the DRG of rats with RTX-induced mechanical allodynia. Therefore, NaV1.7 upregulation in DRG is related to the development of RTX-induced neuropathic pain; moreover, PRF therapy may be effective in the clinical management of patients with PHN via NaV1.7 upregulation inhibition.
言語 en
内容記述
内容記述タイプ Other
内容記述 Citation:
Hidaka K, Maruta T, Koshida T, Kurogi M, Kage Y, Kouroki S, Shirasaka T, Takeya R, Tsuneyoshi I. Extracellular signal-regulated kinase phosphorylation enhancement and NaV1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic pain: The efficacy and mechanism of pulsed radiofrequency therapy. Mol Pain. 2022 Jan-Dec;18:17448069221089784. doi: 10.1177/17448069221089784. PMID: 35418262; PMCID: PMC9019323.
言語 en
書誌情報 en : Molecular Pain

巻 18, p. 174480692210897, 発行日 2022-04-13
出版者
出版者 SAGE
言語 en
ISSN
収録物識別子タイプ ISSN
収録物識別子 1744-8069
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1177/17448069221089784
権利
言語 en
権利情報 © 2023 by SAGE Publications Inc, or the Molecular Pain Group, unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses
著者版フラグ
出版タイプ VoR
戻る
0
views
See details
Views

Versions

Ver.1 2023-11-01 04:49:54.279584
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

日髙, 康太郎, 丸田, 豊明, 越田, 智広, 黒木, 未央, 鹿毛, 陽子, Kouroki Satoshi, 白坂, 哲朗, 武谷, 立, 恒吉, 勇男, 2022, Extracellular signal-regulated kinase phosphorylation enhancement and NaV1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic pain: The efficacy and mechanism of pulsed radiofrequency therapy: SAGE, 174480692210897– p.

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3