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Pivotal role of CD103 in the development of psoriasiform dermatitis
http://hdl.handle.net/10458/0002000183
http://hdl.handle.net/10458/00020001831143f1c6-e828-410a-81c4-fd1cc6ef7477
| 名前 / ファイル | ライセンス | アクション |
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本文 (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||
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| 公開日 | 2023-10-30 | |||||||||||||||||||||||||||||
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| タイトル | Pivotal role of CD103 in the development of psoriasiform dermatitis | |||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||||||||||||
| 著者 |
Fukui Takehito
× Fukui Takehito
× Fukaya Tomohiro
× Uto Tomofumi
× Takagi Hideaki
× Nasu Junta
× Miyanaga Noriaki
× Nishikawa Yotaro
× Koseki Haruhiko
× Choijookhuu Narantsog
× Hishikawa Yoshitaka
× Yamashita Yoshihiro
× Sato Katsuaki
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| 抄録 | ||||||||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||||
| 内容記述 | The integrin αE known as CD103 binds integrin β7 to form the complete heterodimeric integrin molecule αEβ7. CD103 is mainly expressed by lymphocytes within epithelial tissues of intestine, lung, and skin as well as subsets of mucosal and dermal conventional dendritic cells (cDCs). CD103 has been originally implicated in the attachment of lymphocytes to epithelium in the gut and skin through the interaction with E-cadherin expressed on intestinal epithelial cells, keratinocytes, and Langerhans cells (LCs). However, an impact of CD103 on the cutaneous immune responses and the development of inflammatory skin diseases remains elusive. Here, we report that CD103 regulates the development of psoriasiform dermatitis through the control of the function of cDCs. Deficiency in CD103 exacerbates psoriasiform dermatitis, accompanied by excessive epidermal hyperplasia and infiltration of inflammatory leukocytes. Furthermore, deficiency in CD103 not only accelerates the production of proinflammatory cytokines in psoriatic lesions but also promotes the generation of lymphocytes producing interleukin (IL)-17 in the skin-draining peripheral lymph nodes (PLNs). Under the deficiency in CD103, cDCs localized in PLNs enhance cytokine production following activation. Thus, our findings reveal a pivotal role for CD103 in the control of the function of cDCs to regulate cutaneous inflammation in psoriasiform dermatitis. | |||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||||||||
| 内容記述 | Citation: Fukui T, Fukaya T, Uto T, Takagi H, Nasu J, Miyanaga N, Nishikawa Y, Koseki H, Choijookhuu N, Hishikawa Y, Yamashita Y, Sato K. Pivotal role of CD103 in the development of psoriasiform dermatitis. Sci Rep. 2020 May 20;10(1):8371. doi: 10.1038/s41598-020-65355-9. Erratum in: Sci Rep. 2020 Sep 29;10(1):16375. PMID: 32433498; PMCID: PMC7239860. |
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| 言語 | en | |||||||||||||||||||||||||||||
| 書誌情報 |
en : Scientific Reports 巻 10, 号 1, p. 8371 (2020), 発行日 2020-05-20 |
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| 出版者 | Springer Nature | |||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-020-65355-9 | |||||||||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| 権利情報 | © The Author(s) 2020 | |||||||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||||||
