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Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice
http://hdl.handle.net/10458/0002000172
http://hdl.handle.net/10458/0002000172223003c6-3fbf-4505-ba42-278b8b948320
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本文 (8.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2023-10-27 | |||||||||||||
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| タイトル | Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice | |||||||||||||
| 言語 | en | |||||||||||||
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| 言語 | eng | |||||||||||||
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| 資源タイプ | journal article | |||||||||||||
| 著者 |
大園, 芳範
× 大園, 芳範× 幣, 光太郎× 亀田, 拓郎× 上運天, 綾子× Tahira, Yuki× 関根, 雅明× 秋月, 渓一× 中村, 憲一× 岩切, 久芳× 末田, 光恵× 日髙, 智徳× 久冨木, 庸子× 山本, 章二朗× 蓮池, 悟× 澤口, 朗× 永田, 賢治× 下田, 和哉
WEKO
7997
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| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by clonal myeloproliferation, progressive bone marrow (BM) fibrosis, splenomegaly, and anemia. BM fibrosis was previously thought to be a reactive phenomenon induced by mesenchymal stromal cells that are stimulated by the overproduction of cytokines such as transforming growth factor (TGF)-β1. However, the involvement of neoplastic fibrocytes in BM fibrosis was recently reported. In this study, we showed that the vast majority of collagen- and fibronectin-producing cells in the BM and spleens of Jak2V617F-induced myelofibrosis (MF) mice were fibrocytes derived from neoplastic hematopoietic cells. Neoplastic monocyte depletion eliminated collagen- and fibronectin-producing fibrocytes in BM and spleen, and ameliorated most characteristic MF features in Jak2V617F transgenic mice, including BM fibrosis, anemia, and splenomegaly, while had little effect on the elevated numbers of megakaryocytes and stem cells in BM, and leukothrombocytosis in peripheral blood. TGF-β1, which was produced by hematopoietic cells including fibrocytes, promoted the differentiation of neoplastic monocytes to fibrocytes, and elevated plasma TGF-β1 levels were normalized by monocyte depletion. Collectively, our data suggest that neoplastic fibrocytes are the major contributor to BM fibrosis in PMF, and TGF-β1 is required for their differentiation. | |||||||||||||
| 言語 | en | |||||||||||||
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| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | Citation: Ozono, Y., Shide, K., Kameda, T., Kamiunten, A., Tahira, Y., Sekine, M., Akizuki, K., Nakamura, K., Iwakiri, H., Sueta, M., Hidaka, T., Kubuki, Y., Yamamoto, S., Hasuike, S., Sawaguchi, A., Nagata, K., & Shimoda, K. (2021). Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice. Leukemia, 35(2), 454–467. https://doi.org/10.1038/s41375-020-0880-3 |
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| 言語 | en | |||||||||||||
| 書誌情報 |
en : Leukemia 巻 35, 号 2, p. 454-467, 発行日 2020-05-29 |
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| 出版者 | Springer Nature | |||||||||||||
| 言語 | en | |||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0887-6924 | |||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41375-020-0880-3 | |||||||||||||
| 権利 | ||||||||||||||
| 言語 | en | |||||||||||||
| 権利情報 | © The Author(s) 2020. This article is published with open access | |||||||||||||
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| 出版タイプ | VoR | |||||||||||||
