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Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents
http://hdl.handle.net/10458/0002000171
http://hdl.handle.net/10458/0002000171da2c941b-26f6-4045-a819-d488b42efd22
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2023-10-27 | |||||||
| タイトル | ||||||||
| タイトル | Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ | journal article | |||||||
| 著者 |
イスラム, エムディ ヌルル
× イスラム, エムディ ヌルル× Mita Yuichiro
× 丸山, 圭介× Tanida, Ryota× 張, 維東× 迫田, 秀之× 中里, 雅光 |
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Ghrelin, a stomach-derived peptide, promotes feeding and growth hormone (GH) secretion. A recent study identified liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous inhibitor of ghrelin-induced GH secretion, but the effect of LEAP2 in the brain remained unknown. In this study, we showed that intracerebroventricular (i.c.v.) administration of LEAP2 to rats suppressed central ghrelin functions including Fos expression in the hypothalamic nuclei, promotion of food intake, blood glucose elevation, and body temperature reduction. LEAP2 did not inhibit neuropeptide Y (NPY)-induced food intake or des-acyl ghrelin-induced reduction in body temperature, indicating that the inhibitory effects of LEAP2 were specific for GHSR. Plasma LEAP2 levels varied according to feeding status and seemed to be dependent on the hepatic Leap2 expression. Furthermore, ghrelin suppressed the expression of hepatic Leap2 via AMPK activation. Together, these results reveal that LEAP2 inhibits central ghrelin functions and crosstalk between liver and stomach. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Citation: Islam, M. N., Mita, Y., Maruyama, K., Tanida, R., Zhang, W., Sakoda, H., & Nakazato, M. (2020). Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents. The Journal of endocrinology, 244(1), 13–23. https://doi.org/10.1530/JOE-19-0102 |
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| 言語 | en | |||||||
| 書誌情報 |
en : Journal of Endocrinology 巻 244, 号 1, p. 13-23, 発行日 2020-01 |
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| 出版者 | ||||||||
| 出版者 | Bioscientifica | |||||||
| 言語 | en | |||||||
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| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0022-0795 | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1530/JOE-19-0102 | |||||||
| 権利 | ||||||||
| 言語 | en | |||||||
| 権利情報 | © 2020 The authors | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
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イスラム, エムディ ヌルル, Mita Yuichiro, 丸山, 圭介, Tanida, Ryota, 張, 維東, 迫田, 秀之, 中里, 雅光, 2020, Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents: Bioscientifica, 13–23 p.
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