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Multidrug-Resistant ESBL/AmpC-Producing Klebsiella pneumoniae Isolated from Healthy Thoroughbred Racehorses in Japan
http://hdl.handle.net/10458/0002000158
http://hdl.handle.net/10458/00020001582dc90f54-3ece-486d-b187-f1bba16715a1
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本文 (657 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2023-10-26 | |||||||||||
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| タイトル | Multidrug-Resistant ESBL/AmpC-Producing Klebsiella pneumoniae Isolated from Healthy Thoroughbred Racehorses in Japan | |||||||||||
| 言語 | en | |||||||||||
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| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| キーワード | extended-spectrum β-lactamase | |||||||||||
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| 言語 | en | |||||||||||
| キーワード | AmpC β-lactamase | |||||||||||
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| 言語 | en | |||||||||||
| キーワード | Klebsiella pneumoniae | |||||||||||
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| 言語 | en | |||||||||||
| キーワード | horse | |||||||||||
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| 言語 | en | |||||||||||
| キーワード | multidrug resistance | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
エディ, スクマウィナタ
× エディ, スクマウィナタ× 上村, 涼子
WEKO
33773
× Sato, Wataru× Htun, Myo Thu× 末吉, 益雄 |
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Extended-spectrum β-lactamase (ESBL)- and AmpC β-lactamase (AmpC)-producing Klebsiella spp. have become a major health problem, leading to treatment failure in humans and animals. This study aimed to evaluate the presence of ESBL/AmpC-producing Klebsiella spp. isolated from racehorses in Japan. Feces samples from 212 healthy Thoroughbred racehorses were collected from the Japan Racing Association Training Centers between March 2017 and August 2018. ESBL/AmpC-producing Klebsiella spp. were isolated using selective medium containing 1 µg/mL cefotaxime. All isolates were subjected to bacterial species identification (MALDI-TOF MS), antimicrobial susceptibility test (disk diffusion test), characterization of resistance genes (PCR), conjugation assay, and genetic relatedness (multilocus sequence typing/MLST). Twelve ESBL/AmpC-producing Klebsiella pneumoniae (ESBL/AmpC-KP) were isolated from 3.3% of horse samples. Antimicrobial resistance profiling for 17 antimicrobials showed all ESBL/AmpC-KP were multidrug-resistant (MDR). Only 1 isolate was confirmed as an ESBL producer (blaCTX-M-2-positive), whereas the other 11 isolates were plasmid-mediated AmpC (pAmpC) producers (blaCMY positive). On the basis of MLST analysis, the ESBL-KP isolate was identified as sequence type (ST)-133 and four different STs among AmpC-KP isolates, ST-145, ST-4830, ST-4831, and ST-4832, were found to share six of the seven loci constituting a single-locus variant. This is the first study to show K. pneumoniae carrying MDR pAmpC isolated from a racehorse. | |||||||||||
| 言語 | en | |||||||||||
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| 内容記述タイプ | Other | |||||||||||
| 内容記述 | Citation: Sukmawinata, E.; Uemura, R.; Sato, W.; Thu Htun, M.; Sueyoshi, M. Multidrug-Resistant ESBL/AmpC-Producing Klebsiella pneumoniae Isolated from Healthy Thoroughbred Racehorses in Japan. Animals 2020, 10, 369. https://doi.org/10.3390/ani10030369 |
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| 言語 | en | |||||||||||
| 書誌情報 |
en : Animals 巻 10, 号 3, p. 369, 発行日 2020-02-25 |
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| 出版者 | ||||||||||||
| 出版者 | MDPI | |||||||||||
| 言語 | en | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.3390/ani10030369 | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
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エディ, スクマウィナタ, 上村, 涼子, Sato, Wataru, Htun, Myo Thu, 末吉, 益雄, 2020, Multidrug-Resistant ESBL/AmpC-Producing Klebsiella pneumoniae Isolated from Healthy Thoroughbred Racehorses in Japan: MDPI, 369– p.
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