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Involvement of the NADPH oxidase 2 pathway in renal oxidative stress in Aqp11-/- mice
http://hdl.handle.net/10458/0002000116
http://hdl.handle.net/10458/0002000116231b5b85-faf2-4358-a55d-df56f0ac5b1b
| 名前 / ファイル | ライセンス | アクション |
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本文 (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2023-10-24 | |||||||||||||||||||
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| タイトル | Involvement of the NADPH oxidase 2 pathway in renal oxidative stress in Aqp11-/- mice | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| キーワード | Aquaporin-11 | |||||||||||||||||||
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| 言語 | en | |||||||||||||||||||
| キーワード | Polycystic kidney disease | |||||||||||||||||||
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| 言語 | en | |||||||||||||||||||
| キーワード | Oxidative stress | |||||||||||||||||||
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| 言語 | en | |||||||||||||||||||
| キーワード | Hypoxia | |||||||||||||||||||
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| 言語 | en | |||||||||||||||||||
| キーワード | Renal failure | |||||||||||||||||||
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| 言語 | en | |||||||||||||||||||
| キーワード | Pathway analysis | |||||||||||||||||||
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| 言語 | en | |||||||||||||||||||
| キーワード | NOX2 | |||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||
| アクセス権 | ||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||
| 著者 |
星野, 雄也
× 星野, 雄也× 園田, 紘子
WEKO
5451
× Nishimura, Ryuji× 森, 和也× Ishibashi, Kenichi
× 池田, 正浩
WEKO
1081
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Aquaporin-11 (AQP11) is an intracellular AQP. Several studies with Aqp11-/- mice have shown that AQP11 has a role in normal development of the kidney after birth. Our previous studies have suggested that alteration of oxygen homeostasis may be involved in the kidney injury caused by AQP11 deficiency, although the underlying mechanism is largely unknown. To clarify this issue, we examined genes that are related to oxygen homeostasis in Aqp11-/- mice. Among 62 genes that are involved in oxygen homeostasis, 35 were upregulated by more than 2-fold in Aqp11-/- mice in comparison with wild-type mice. Pathway analysis using these genes extracted the pathway responsible for production of reactive oxygen species in macrophages. As expression of the genes involved in the NADPH oxidase 2 (NOX2) complex was dramatically increased by more than 14-fold, we further analyzed NOX2 at the protein level. Immunoblotting analysis demonstrated a dramatic increase of NOX2 protein in the kidney of Aqp11-/- mice, and immunohistochemistry showed that NOX2 protein and a marker protein for macrophages were increased in the renal interstitium. These results indicate that NOX2-induced oxidative stress accompanied by macrophage infiltration plays an important role in alteration of oxygen homeostasis in Aqp11-/- mice. | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | Yuya Hoshino, Hiroko Sonoda, Ryuji Nishimura, Kazuya Mori, Kenichi Ishibashi, Masahiro Ikeda, Involvement of the NADPH oxidase 2 pathway in renal oxidative stress in Aqp11-/- mice, Biochemistry and Biophysics Reports, Volume 17, 2019, Pages 169-176, ISSN 2405-5808, https://doi.org/10.1016/j.bbrep.2019.01.003. |
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| 言語 | en | |||||||||||||||||||
| 書誌情報 |
en : Biochemistry and Biophysics Reports 巻 17, p. 169-176, 発行日 2019-03 |
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| 出版者 | ||||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 24055808 | |||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.bbrep.2019.01.003 | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 権利情報 | © 2019 The Authors. Published by Elsevier B.V. | |||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||
