| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-10-24 |
| タイトル |
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|
タイトル |
Dysregulated HAI-2 Plays an Important Role in Renal Cell Carcinoma Bone Metastasis through Ligand-Dependent MET Phosphorylation |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
RCC |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
bone metastasis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
HGF |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
キーワード |
MET |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
キーワード |
HAI-2 |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
山崎, 浩司
向井, 尚一郎
WEKO
26958
| en |
Mukai, Shoichiro
Mukai, Syoichiro
|
| ja |
向井, 尚一郎
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| ja-Kana |
ムカイ, ショウイチロウ
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|
Search repository
杉江, 悟
永井, 崇敬
中原, 梢
上別府, 豊治
Sakamoto, Hiromasa
Shibasaki, Noboru
Terada, Naoki
Toda, Yoshinobu
片岡, 寛章
賀本, 敏行
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
MET, a c-met proto-oncogene product and hepatocyte growth factor (HGF) receptor, is known to play an important role in cancer progression, including bone metastasis. In a previous study, we reported increased expression of MET and matriptase, a novel activator of HGF, in bone metastasis. In this study, we employed a mouse model of renal cell carcinoma (RCC) bone metastasis to clarify the significance of the HGF/MET signaling axis and the regulator of HGF activator inhibitor type-2 (HAI-2). Luciferase-transfected 786-O cells were injected into the left cardiac ventricle of mice to prepare the mouse model of bone metastasis. The formation of bone metastasis was confirmed by whole-body bioluminescent imaging, and specimens were extracted. Expression of HGF/MET-related molecules was analyzed. Based on the results, we produced HAI-2 stable knockdown 786-O cells, and analyzed invasiveness and motility. Expression of HGF and matriptase was increased in bone metastasis compared with the control, while that of HAI-2 was decreased. Furthermore, we confirmed increased phosphorylation of MET in bone metastasis. The expression of matriptase was upregulated, and both invasiveness and motility were increased significantly by knockdown of HAI-2. The significance of ligand-dependent MET activation in RCC bone metastasis is considered, and HAI-2 may be an important regulator in this system. |
|
言語 |
en |
| 内容記述 |
|
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内容記述タイプ |
Other |
|
内容記述 |
Yamasaki, K.; Mukai, S.; Sugie, S.; Nagai, T.; Nakahara, K.; Kamibeppu, T.; Sakamoto, H.; Shibasaki, N.; Terada, N.; Toda, Y.; et al. Dysregulated HAI-2 Plays an Important Role in Renal Cell Carcinoma Bone Metastasis through Ligand-Dependent MET Phosphorylation. Cancers 2018, 10, 190. https://doi.org/10.3390/cancers10060190 |
|
言語 |
en |
| 書誌情報 |
en : Cancers
巻 10,
号 6,
p. 190,
発行日 2018-06-08
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| 出版者 |
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出版者 |
MDPI |
|
言語 |
en |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/cancers10060190 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| 著者版フラグ |
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出版タイプ |
VoR |
本文 (38.8 MB)
