| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-09-27 |
| タイトル |
|
|
タイトル |
Congenital Deficiency of Conventional Dendritic Cells Promotes the Development of Atopic Dermatitis-Like Inflammation |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
atopic dermatitis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
dendritic cells, |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
type 2 immune responses |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
immune homeostasis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
キーワード |
homeostatic feedback loop |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
西川, 陽太郎
深谷, 知宏
Fukui, Takehito
宇都, 倫史
Takagi, Hideaki
Nasu, Junta
Miyanaga, Noriaki
Riethmacher, Dieter
チヨウジヨウフ, ナランツオツク
菱川, 善隆
天野, 正宏
佐藤, 克明
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Atopic dermatitis (AD) is a common pruritic inflammatory skin disease characterized by impaired epidermal barrier function and dysregulation of Thelper-2 (TH2)-biased immune responses. While the lineage of conventional dendritic cells (cDCs) are implicated to play decisive roles in T-cell immune responses, their requirement for the development of AD remains elusive. Here, we describe the impact of the constitutive loss of cDCs on the progression of AD-like inflammation by using binary transgenic (Tg) mice that constitutively lacked CD11chi cDCs. Unexpectedly, the congenital deficiency of cDCs not only exacerbates the pathogenesis of AD-like inflammation but also elicits immune abnormalities with the increased composition and function of granulocytes and group 2 innate lymphoid cells (ILC2) as well as B cells possibly mediated through the breakdown of the Fms-related tyrosine kinase 3 ligand (Flt3L)-mediated homeostatic feedback loop. Furthermore, the constitutive loss of cDCs accelerates skin colonization of Staphylococcus aureus (S. aureus), that associated with disease flare. Thus, cDCs maintains immune homeostasis to prevent the occurrence of immune abnormalities to maintain the functional skin barrier for mitigating AD flare. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Citation:
Nishikawa Y, Fukaya T, Fukui T, Uto T, Takagi H, Nasu J, Miyanaga N, Riethmacher D, Choijookhuu N, Hishikawa Y, Amano M and Sato K (2021) Congenital Deficiency of Conventional Dendritic Cells Promotes the Development of Atopic Dermatitis-Like Inflammation. Front. Immunol. 12:712676. doi: 10.3389/fimmu.2021.712676 |
|
言語 |
en |
| 書誌情報 |
en : Frontiers in Immunology
巻 12,
p. 712676,
発行日 2021-07-27
|
| 出版者 |
|
|
出版者 |
Frontiers Media S.A. |
|
言語 |
en |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3389/fimmu.2021.712676 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2021 Nishikawa, Fukaya, Fukui, Uto, Takagi, Nasu, Miyanaga, Riethmacher, Choijookhuu, Hishikawa, Amano and Sato. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
本文 (8.7 MB)
