WEKO3
-
RootNode
アイテム
PER3 polymorphisms and their association with prostate cancer risk in Japanese men
http://hdl.handle.net/10458/0002000078
http://hdl.handle.net/10458/0002000078a3c4ba2a-2f76-44ed-a9f3-593ef5b1b4d8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Fulltext (125 KB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-09-17 | |||||
| タイトル | ||||||
| タイトル | PER3 polymorphisms and their association with prostate cancer risk in Japanese men | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Prostate cancer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | PER3 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | polymorphism | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | rs2640908 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | VNTR | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
日野浦, 拓之
× 日野浦, 拓之× 向井, 尚一郎× 賀本, 敏行× 黒田, 嘉紀 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: Prostate cancer (PCa) is one of the most common cancers affecting men globally. Although PER3 has been suggested as a risk factor for cancer development, there are few reports elucidating the relationship between PER3 and PCa. We investigated the association between PER3 polymorphisms (rs2640908 and VNTR) and susceptibility to PCa in the Japanese population. Methods: Eighty three patients with PCa and 122 controls participated in this study. We analyzed rs2640908 and VNTR polymorphisms by using PCR–Restriction Fragment Length Polymorphism (PCR–RFLP). Results: Compared to the C/C genotype with the rs2640908 polymorphism, the T/T (OR: 0.35, 95% CI: 0.15–0.81, P = 0.02) and C/T + T/T (OR: 0.46, 95% CI: 0.24–0.88, P = 0.02) genotypes had a significantly lower risk of PCa. TT (OR: 0.29, 95% CI: 0.10–0.77, P = 0.02) and CT + TT (OR: 0.47, 95% CI: 0.23–0.97, P = 0.04) also had significant protection against PCa in the smoker group. Significantly, we observed an association between smoking and rs2640908 polymorphism in this study. However, no association between the VNTR polymorphisms and PCa was detected. Conclusions: Our results suggest that PER3 rs2640908 polymorphisms influence an individual’s susceptibility to PCa. |
|||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Hinoura T, Mukai S, Kamoto T, Kuroda Y. PER3 polymorphisms and their association with prostate cancer risk in Japanese men. J Prev Med Hyg. 2021 Jul 30;62(2):E489-E495. doi: 10.15167/2421-4248/jpmh2021.62.2.1865. Erratum in: J Prev Med Hyg. 2021 Sep 15;62(3):E789. PMID: 34604590; PMCID: PMC8451342. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Journal of Preventive Medicine and Hygiene 巻 62, 号 2, p. E489-E495, 発行日 2021-07-30 |
|||||
| 出版者 | ||||||
| 出版者 | Pacini editore | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1121-2233 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.15167/2421-4248/jpmh2021.62.2.1865 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © Copyright by Pacini Editore Srl, Pisa, Italy This is an open access article distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license. The article can be used by giving appropriate credit and mentioning the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
Share
Cite as
日野浦, 拓之, 向井, 尚一郎, 賀本, 敏行, 黒田, 嘉紀, n.d., PER3 polymorphisms and their association with prostate cancer risk in Japanese men: Pacini editore, E489–E495 p.
Loading...
