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Proportion of fibrin and platelets differs in thrombi on ruptured and eroded coronary atherosclerotic plaques in humans
http://hdl.handle.net/10458/1379
http://hdl.handle.net/10458/137903c1dfc8-2a96-4944-903f-d9ee771c7a5d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
asada heart 91(4)2005.pdf (389.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2008-03-17 | |||||
| タイトル | ||||||
| タイトル | Proportion of fibrin and platelets differs in thrombi on ruptured and eroded coronary atherosclerotic plaques in humans | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | thrombus, acute myocardial infarction, fibrin, platelet | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Sato, Y.
× Sato, Y.× Hatakeyama, K.× Yamashita, A.× Marutsuka, K.× Sumiyoshi, A.× 浅田, 祐士郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: To determine the proportion of platelets and fibrin in coronary thrombi. Design: Immunohistochemical and morphometric means to examine the coronary arteries of 31 patients who died of acute myocardial infarction. Results: Fresh thrombi were detected in the feeding arteries of infarction areas in 23 cases （74%） and were associated with plaque rupture in 18 （78%） and plaque erosion in 5 （22%）. An immunohistochemical study showed that the thrombi consisted of a mixture of fibrin and platelets as well as some other types of blood cells. The fibrin and platelet positive areas in the thrombi associated with plaque rupture accounted for 74 （19）% and 35 （20）% （p < 0.01） and those associated with erosion accounted for 51 （6）% and 70 （21）%, respectively, of the total areas. Areas of positive immunoreactivity for tissue factor and C reactive protein were also significantly greater in ruptured than in eroded plaques. Conclusion: These results indicate that the proportions of fibrin and of platelets differ in coronary thrombi on ruptured and eroded plaques. Higher proportions of tissue factor and C reactive protein contribute more significantly to thrombus formation on plaque rupture than on plaque erosion. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Heart 巻 91, 号 4, p. 526-530, 発行日 2005-04 |
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| 出版者 | ||||||
| 出版者 | BMJ Publishing Group | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13556037 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11059124 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
