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  1. 医学部
  1. 医学部
  2. 学術雑誌掲載論文  (医学部)

Proportion of fibrin and platelets differs in thrombi on ruptured and eroded coronary atherosclerotic plaques in humans

http://hdl.handle.net/10458/1379
http://hdl.handle.net/10458/1379
03c1dfc8-2a96-4944-903f-d9ee771c7a5d
名前 / ファイル ライセンス アクション
asada_heart_91-4-2005.pdf asada heart 91(4)2005.pdf (389.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-03-17
タイトル
タイトル Proportion of fibrin and platelets differs in thrombi on ruptured and eroded coronary atherosclerotic plaques in humans
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
キーワード thrombus, acute myocardial infarction, fibrin, platelet
資源タイプ
資源タイプ journal article
著者 Sato, Y.

× Sato, Y.

WEKO 9749

en Sato, Y.

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Hatakeyama, K.

× Hatakeyama, K.

WEKO 9750

en Hatakeyama, K.

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Yamashita, A.

× Yamashita, A.

WEKO 9751

en Yamashita, A.

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Marutsuka, K.

× Marutsuka, K.

WEKO 9752

en Marutsuka, K.

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Sumiyoshi, A.

× Sumiyoshi, A.

WEKO 9753

en Sumiyoshi, A.

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浅田, 祐士郎

× 浅田, 祐士郎

WEKO 7742
e-Rad 70202588

en Asada, Yujiro

ja 浅田, 祐士郎

ja-Kana アサダ , ユウジロウ


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抄録
内容記述タイプ Abstract
内容記述 Objective: To determine the proportion of platelets and fibrin in coronary thrombi. Design: Immunohistochemical and morphometric means to examine the coronary arteries of 31 patients who died of acute myocardial infarction. Results: Fresh thrombi were detected in the feeding arteries of infarction areas in 23 cases (74%) and were associated with plaque rupture in 18 (78%) and plaque erosion in 5 (22%). An immunohistochemical study showed that the thrombi consisted of a mixture of fibrin and platelets as well as some other types of blood cells. The fibrin and platelet positive areas in the thrombi associated with plaque rupture accounted for 74 (19)% and 35 (20)% (p < 0.01) and those associated with erosion accounted for 51 (6)% and 70 (21)%, respectively, of the total areas. Areas of positive immunoreactivity for tissue factor and C reactive protein were also significantly greater in ruptured than in eroded plaques. Conclusion: These results indicate that the proportions of fibrin and of platelets differ in coronary thrombi on ruptured and eroded plaques. Higher proportions of tissue factor and C reactive protein contribute more significantly to thrombus formation on plaque rupture than on plaque erosion.
言語 en
書誌情報 en : Heart

巻 91, 号 4, p. 526-530, 発行日 2005-04
出版者
出版者 BMJ Publishing Group
言語 en
ISSN
収録物識別子タイプ ISSN
収録物識別子 13556037
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11059124
著者版フラグ
出版タイプ VoR
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