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Different Inflammatory Response and Oxidative Stress in Neointimal Hyperplasia after Balloon Angioplasty and Stent Implantation in Cholesterol-fed Rabbits
http://hdl.handle.net/10458/1376
http://hdl.handle.net/10458/1376681cca6a-7f68-41f1-8f76-07dc226fb64a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
asada pat res practice202(6)2006.pdf (557.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-03-17 | |||||
| タイトル | ||||||
| タイトル | Different Inflammatory Response and Oxidative Stress in Neointimal Hyperplasia after Balloon Angioplasty and Stent Implantation in Cholesterol-fed Rabbits | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | balloon angioplasty, CRP, oxidative stress, restenosis, stents | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| その他（別言語等）のタイトル | ||||||
| その他のタイトル | CRP and oxidative stress in restenosis after ballooning and stenting. | |||||
| 言語 | en | |||||
| 著者 |
Kawamoto, Riichirou
× Kawamoto, Riichirou× Yamashita, Atsushi× Nishihira, Kensaku× Furukoji, Eiji× Hatakeyama, Kinta× Ishikawa, Tetsunori× Imamura, Takuroh× Itabe, Hiroyuki× Eto, Tanenao× Asada, Yujiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Inflammatory responses appear to play an important role in the occurrence of restenosis following coronary intervention. However, contribution of C-reactive protein (CRP) and oxidative stress to restenosis after balloon angioplasty and stent implantation remains unclear. The aim of this study is to examine this issue using hyperlipidemic rabbits. Rabbits were divided into two groups; fed with a 0.5% cholesterol diet and fed with a mixed 0.5% cholesterol and 0.5% probucol diet. Each group of rabbits underwent balloon injury and stent implantation in right and left iliac arteries, respectively. Eight weeks after intervention, we examined luminal stenosis, neointimal hyperplasia, immunoreactivity for macrophage, CRP and oxidized phosphatidylcholine (oxPC), and also expression of CRP mRNA. The degrees of neointimal hyperplasia and immunopositive areas (%) for macrophage, CRP and oxPC in the neointima were significantly higher after stent implantation than after balloon injury, but CRP mRNA was undetectable in either artery. Anti-oxidant probucol reduced angiographic stenosis, neointimal hyperplasia, macrophage- and oxPC-positive areas much more significantly after stenting. The results demonstrate that inflammatory response to the development of neointimal hyperplasia differs after balloon injury and stent implantation and that CRP deposition and oxidative stress might be involved more significantly in neointimal development after stent implantation. |
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| 言語 | en | |||||
| 書誌情報 |
en : Pathology, research and practice 巻 202, 号 6, p. 447-456, 発行日 2006-06-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03440338 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00769966 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
