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BBF2H7, a Novel Transmembrane bZIP Transcription Factor, Is a New Type of Endoplasmic Reticulum Stress Transducer
http://hdl.handle.net/10458/2335
http://hdl.handle.net/10458/2335df727cf7-2dc1-4414-906e-da31e428c394
| 名前 / ファイル | ライセンス | アクション |
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1716[1].pdf (846.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-09-28 | |||||
| タイトル | ||||||
| タイトル | BBF2H7, a Novel Transmembrane bZIP Transcription Factor, Is a New Type of Endoplasmic Reticulum Stress Transducer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
近藤, 慎一
× 近藤, 慎一× 斎藤, 敦× Hino, Shin-ichiro× Murakami, Tomohiko× Ogata, Maiko× 金本, 聡自× Nara, Satoshi× Yamashita, Akinori× Yoshinaga, Kazuya× Hara, Hideaki× Imaizumi, Kazunori |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Eukaryotic cells deal with accumulation of unfolded proteins in the endoplasmic reticulum （ER） by the unfolded protein response, involving the induction of molEndoplasmic reticulum （ER） stress transducers IRE1 （inositol requiring 1）, PERK （PKR-like endoplasmic reticulum kinase）, and ATF6 （activating transcription factor 6） are well known to transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins accumulate in the ER. Recently, we identified OASIS （old astrocyte specifically induced substance） as a novel ER stress transducer expressed in astrocytes. We report here that BBF2H7 （BBF2 human homolog on chromosome 7）, an ER-resident transmembrane protein with the bZIP domain in the cytoplasmic portion and structurally homologous to OASIS, is cleaved at the membrane in response to ER stress. The cleaved fragments of BBF2H7 translocate into the nucleus and can bind directly to cyclic AMP-responsive element sites to activate transcription of target genes. Interestingly, although BBF2H7 protein is not expressed under normal conditions, it is markedly induced at the translational level during ER stress, suggesting that BBF2H7 might contribute to only the late phase of unfolded protein response signaling. In a mouse model of focal brain ischemia, BBF2H7 protein is prominently induced in neurons in the peri-infarction region. Furthermore, in a neuroblastoma cell line, BBF2H7 overexpression suppresses ER stress-induced cell death, while small interfering RNA knockdown of BBF2H7 promotes ER stress-induced cell death. Taken together, our results suggest that BBF2H7 is a novel ER stress transducer and could play important roles in preventing accumulation of unfolded proteins in damaged neurons. |
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| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Copyright © 2009, American Society for Microbiology. All Rights Reserved. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Molecular and cellular biology 巻 27, 号 5, p. 1716-1729, 発行日 2007-03 |
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| 出版者 | ||||||
| 出版者 | American Society for Microbiology | |||||
| 言語 | en | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 02707306 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10620925 | |||||
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| 出版タイプ | VoR | |||||
