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Recent therapeutic strategies improve renal outcome in patients with IgA nephropathy
http://hdl.handle.net/10458/2259
http://hdl.handle.net/10458/225947d67dcc-9773-438b-a1da-d270a6e97c6e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
komatsuAJNE2009.pdf (223.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-09-04 | |||||
| タイトル | ||||||
| タイトル | Recent therapeutic strategies improve renal outcome in patients with IgA nephropathy | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | IgA nephropathy, Renal outcome, Tonsillectomy, Steroid therapy, Renin-angiotensin system inhibitor | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
小松, 弘幸
× 小松, 弘幸× 藤元, 昭一× 北村, 和雄× Hara, Seiichiro× Fukuda, Akihiro× Fukudome, Keiichi× Yamada, Kazuhiro× Sato, Yuji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/Aims: Various treatment options for IgA nephropathy （IgAN） have been developed, particularly over the past decade. Nevertheless, whether such the therapeutic interventions improve actual renal outcome as compared with previous therapies remains obscure. Methods: We examined data from 304 patients with IgAN whose serum creatinine value at renal biopsy was <2.0 mg/dl and who had been followed up for >12 months. We assigned the patients to groups according to the period of diagnosis （group E, between 1981 and 1995, n=130; group L, between 1996 and 2006, n=174）. Results: Significantly more patients had received steroid therapy and renin-angiotensin system inhibitors （RAS-I） in group L than in group E （steroid: 51.7 vs. 15.4%, p<0.001; RAS-I: 42.0 vs. 1.5%, p<0.001）. Forty patients overall reached end-stage renal disease （ESRD） within 81.9±55.1 months of observation. Kaplan-Meier analysis showed that ten-year renal survival rate of group L persisted and significantly differed from that of group E （95.7 vs. 75.2%, p=0.005）. The Cox proportional hazards model adjusted for known prognostic markers demonstrated that initial therapeutic interventions in group L prevented ESRD, with hazard ratio of 0.29 （95% C.I., 0.11 to 0.76, p=0.011）. Conclusion: Although this study is not a prospective trial, our results indicate that aggressive therapeutic intervention for IgAN over the past decade has improved actual renal outcome. |
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| 言語 | en | |||||
| 書誌情報 |
en : American journal of nephrology 巻 30, 号 1, p. 19-25, 発行日 2009-07 |
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| 出版者 | ||||||
| 出版者 | Karger | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 02508095 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10424676 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 19169006 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1159/000197116 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
