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Nitroprusside Inhibits Kindling Development and Potentiates Excitatory Amino Acid Exocytosis in the Kindling Rat
http://hdl.handle.net/10458/2164
http://hdl.handle.net/10458/216459ccf0e6-5f28-4387-9c7f-ec2eb0222c2c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2-5a.pdf (681.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-08-17 | |||||
| タイトル | ||||||
| タイトル | Nitroprusside Inhibits Kindling Development and Potentiates Excitatory Amino Acid Exocytosis in the Kindling Rat | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Ueda, Yuto
× Ueda, Yuto× Mitsuyama, Yoshio |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effect of sodium nitroprusside （SNP）, one of the nitric oxide （NO） donors, on the development of acute amygdaloid kindling and amino acid exocytosis in the hippocampus of kindled rats was examined using in vivo microdialysis. The number of stimulations required for rats perfused with 10 mM SNP through the ventral hippocampus prior to the first kindling stimulation was larger than that of control, and the afterdischarge duration was shorter than that of control. On the other hand, SNP-induced enhancement of aspartate, glutamate and glycine overflow in the established kindled rats was greater than that in control. This SNP-induced enhancement of amino acid overflow was TIX-insensitive. These results suggest that NO has at least two roles in kindling; to accelerate amino acid exocytosis, and to inhibit kindling development. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Journal of brain science ja : 日本脳科学会会誌 巻 23, 号 1, p. 49-60, 発行日 1997 |
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| 出版者 | ||||||
| 出版者 | 日本脳科学会 | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13415301 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11081225 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
