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  1. 医学部
  1. 医学部
  2. 学術雑誌掲載論文  (医学部)

Loss of ribosomal RNA modification causes developmental defects in zebrafish.

http://hdl.handle.net/10458/3669
http://hdl.handle.net/10458/3669
c21ed5ed-0c36-4958-8236-229e0e87f764
名前 / ファイル ライセンス アクション
kenmochi_nucleic_acids_res.pdf kenmochi_Nucleic Acids Res .pdf (3.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-05-22
タイトル
タイトル Loss of ribosomal RNA modification causes developmental defects in zebrafish.
言語 en
言語
言語 eng
資源タイプ
資源タイプ journal article
著者 Higa-Nakamine, Sayomi

× Higa-Nakamine, Sayomi

WEKO 8528

en Higa-Nakamine, Sayomi

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Suzuki, Takeo

× Suzuki, Takeo

WEKO 8529

en Suzuki, Takeo

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Uechi, Tamayo

× Uechi, Tamayo

WEKO 9591
e-Rad 10381104

en Uechi, Tamayo

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Chakraborty, Anirban

× Chakraborty, Anirban

WEKO 8531

en Chakraborty, Anirban

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Nakajima, Yukari

× Nakajima, Yukari

WEKO 8532

en Nakajima, Yukari

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Nakamura, Mikako

× Nakamura, Mikako

WEKO 8533

en Nakamura, Mikako

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Hirano, Naoko

× Hirano, Naoko

WEKO 8534

en Hirano, Naoko

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Suzuki, Tsutomu

× Suzuki, Tsutomu

WEKO 8535

en Suzuki, Tsutomu

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Kenmochi, Naoya

× Kenmochi, Naoya

WEKO 7812

en Kenmochi, Naoya

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抄録
内容記述タイプ Abstract
内容記述 Non-coding RNAs (ncRNAs) play key roles in diverse cellular activities, and efficient ncRNA function requires extensive posttranscriptional nucleotide modifications. Small nucleolar RNAs (snoRNAs) are a group of ncRNAs that guide the modification of specific nucleotides in ribosomal RNAs (rRNAs) and small nuclear RNAs. To investigate the physiological relevance of rRNA modification in vertebrates, we suppressed the expression of three snoRNAs (U26, U44 and U78), either by disrupting the host gene splicing or by inhibiting the snoRNA precursor processing, and analyzed the consequences of snoRNA loss-of-function in zebrafish. Using a highly sensitive mass spectrometric analysis, we found that decreased snoRNA expression reduces the snoRNA-guided methylation of the target nucleotides. Impaired rRNA modification, even at a single site, led to severe morphological defects and embryonic lethality in zebrafish, which suggests that rRNA modifications play an essential role in vertebrate development. This study highlights the importance of posttranscriptional modifications and their role in ncRNA function in higher eukaryotes.
言語 en
書誌情報 en : Nucleic acids research

巻 40, 号 1, p. 391-398, 発行日 2012-01
出版者
出版者 Oxford University Press
言語 en
ISSN
収録物識別子タイプ ISSN
収録物識別子 13624962
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 21908402
著者版フラグ
出版タイプ VoR
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Higa-Nakamine, Sayomi, Suzuki, Takeo, Uechi, Tamayo, Chakraborty, Anirban, Nakajima, Yukari, Nakamura, Mikako, Hirano, Naoko, Suzuki, Tsutomu, Kenmochi, Naoya, 2012, Loss of ribosomal RNA modification causes developmental defects in zebrafish.: Oxford University Press, 391–398 p.

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