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Association Between Renal Vasculature Changes and Generalized Atherosclerosis : An Autopsy Survey
http://hdl.handle.net/10458/5467
http://hdl.handle.net/10458/546726a08993-29f4-43d3-9f73-342c72961a54
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-21 | |||||
| タイトル | ||||||
| タイトル | Association Between Renal Vasculature Changes and Generalized Atherosclerosis : An Autopsy Survey | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Renal artery, Cardiovascular disease, Atherosclerosis, Autopsy | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
岩切, 太幹志
× 岩切, 太幹志× 佐藤, 勇一郎× 松浦, 祐之介× 畠山, 金太× 丸塚, 浩助× 山下, 篤× 藤元, 昭一× 北村, 和雄× 浅田, 祐士郎× 丸塚, 浩助 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim: To examine the association between renal vasculature changes and generalized atherosclerosis using autopsy cases. Methods: We histologically examined 107 autopsy patients（mean age, 68.4 years; 64% men; 81% non-CVD） to investigate the association between renal vasculature changes and generalized atherosclerosis. We measured the intima/media （I/M） ratio for the renal, intrarenal and systemic arteries （coronary, cerebral, common carotid and common iliac）, calculated the rates of arteriolar hyalinization and global glomerulosclerosis and evaluated the frequency of advanced lesions （AHA classification ≥ IV） in the systemic arteries. Results: The I/M ratios of the renal and intrarenal arteries and the rate of global glomerulosclerosis increased with age, while the rates of arteriolar hyalinization and global glomerulosclerosis were associated with diabetes and hypertension （all p<0.05）. The I/M ratio of the coronary artery was independently associated with the rate of global glomerulosclerosis （p<0.05）. The frequency of advanced atherosclerotic lesions in the coronary and cerebral arteries was also correlated with the I/M ratio of the renal artery and rates of arteriolar hyalinization and global glomerulosclerosis （all p<0.05）. The frequency of advanced lesions in the cerebral and common carotid arteries was independently associated with the I/M ratio of the renal artery and the rate of renal arteriolar hyalinization （odds ratio （OR） with [95% confidence interval]; 5.09 [1.15-27.9] and 4.11 [1.38-13.9], respectively）. Conclusions: The results of this study demonstrated that pathological changes in four portions of the renal vasculature differ. Renal vasculature changes except the intrarenal arteries were significantly associated with those observed in the cerebral, common carotid and coronary arteries. |
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| 言語 | en | |||||
| 書誌情報 |
en : Journal of Atherosclerosis and Thrombosis 巻 21, 号 2, p. 99-107, 発行日 2012-12 |
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| 出版者 | ||||||
| 出版者 | Japan Atherosclerosis Society | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 日本動脈硬化学会 | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13403478 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
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岩切, 太幹志, 佐藤, 勇一郎, 松浦, 祐之介, 畠山, 金太, 丸塚, 浩助, 山下, 篤, 藤元, 昭一, 北村, 和雄, 浅田, 祐士郎, 丸塚, 浩助, 2012, Association Between Renal Vasculature Changes and Generalized Atherosclerosis : An Autopsy Survey: 日本動脈硬化学会, 99–107 p.
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