@article{oai:miyazaki-u.repo.nii.ac.jp:00004618,
 author = {Iwakiri, Takashi and 岩切, 太幹志 and Sato, Yuichiro and 佐藤, 勇一郎 and Matsuura, Yunosuke and 松浦, 祐之介 and Hatakeyama, Kinta and 畠山, 金太 and 丸塚, 浩助 and Marutsuka, Kousuke and Yamashita, Atsushi and 山下, 篤 and Fujimoto, Shouichi and 藤元, 昭一 and Kitamura, Kazuo and 北村, 和雄 and Asada, Yujiro and 浅田, 祐士郎 and 丸塚, 浩助 and Marutsuka, Kousuke},
 issue = {2},
 journal = {Journal of Atherosclerosis and Thrombosis},
 month = {Dec},
 note = {Aim: To examine the association between renal vasculature changes and generalized atherosclerosis using autopsy cases.
Methods: We histologically examined 107 autopsy patients（mean age, 68.4 years; 64% men; 81% non-CVD） to investigate the association between renal vasculature changes and generalized atherosclerosis. We measured the intima/media （I/M） ratio for the renal, intrarenal and systemic arteries （coronary, cerebral, common carotid and common iliac）, calculated the rates of arteriolar hyalinization and global glomerulosclerosis and evaluated the frequency of advanced lesions （AHA classification ≥ IV） in the systemic arteries.
Results: The I/M ratios of the renal and intrarenal arteries and the rate of global glomerulosclerosis increased with age, while the rates of arteriolar hyalinization and global glomerulosclerosis were associated with diabetes and hypertension （all p<0.05）. The I/M ratio of the coronary artery was independently associated with the rate of global glomerulosclerosis （p<0.05）. The frequency of advanced atherosclerotic lesions in the coronary and cerebral arteries was also correlated with the I/M ratio of the renal artery and rates of arteriolar hyalinization and global glomerulosclerosis （all p<0.05）. The frequency of advanced lesions in the cerebral and common carotid arteries was independently associated with the I/M ratio of the renal artery and the rate of renal arteriolar hyalinization （odds ratio （OR） with [95% confidence interval]; 5.09 [1.15-27.9] and 4.11 [1.38-13.9], respectively）.
Conclusions: The results of this study demonstrated that pathological changes in four portions of the renal vasculature differ. Renal vasculature changes except the intrarenal arteries were significantly associated with those observed in the cerebral, common carotid and coronary arteries.},
 pages = {99--107},
 title = {Association Between Renal Vasculature Changes and Generalized Atherosclerosis : An Autopsy Survey},
 volume = {21},
 year = {2012},
 yomi = {イワキリ, タカシ and サトウ, ユウイチロウ and マツウラ, ユウノスケ and ハタケヤマ, キンタ and マルツカ, コウスケ and ヤマシタ, アツシ and フジモト, シヨウイチ and キタムラ, カズオ and アサダ, ユウジロウ and マルツカ, コウスケ}
}