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ブタ肝臓水解物の成分分析と抗酸化活性及びアンギオテンシン変換酵素 (ACE) 阻害活性の検討
http://hdl.handle.net/10458/4483
http://hdl.handle.net/10458/44832a84f1e2-7711-408b-a887-ac8247e129cd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
muguruma.107-115.pdf (434.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-04-19 | |||||
| タイトル | ||||||
| タイトル | ブタ肝臓水解物の成分分析と抗酸化活性及びアンギオテンシン変換酵素 (ACE) 阻害活性の検討 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Analysis of the Components of Porcine Liver Hydrolysate and Examination of the Antioxidant Activity and Angiotensin Converting Enzyme (ACE)-inhibiting Activity | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | liver hydrolysate, angiotensin converting enzyme (ACE) inhibition, antioxidation, antihypertensive activity | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
井上, 尚典
× 井上, 尚典× 浜崎, 敦子× 日高, 修二× 三浦, 直良× 深堀, 勝博× 丸山, 眞杉× 河原, 聡× 太田, 一良× 六車, 三治男× 井上, 尚典× Hamasaki, Atsuko× Hidaka, Shuji× Miura, Naoyoshi× 深堀, 勝博× 丸山, 眞杉 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hypertension and oxidant stress predispose to the onset and progression of arteriosclerotic diseases. In this study, the components of two kinds of porcine liver hydrolysates （LH-I and LH-II） were analyzed, and the antioxidant effects and angiotensin converting enzyme （ACE）-inhibiting effects of LH-I and LH-II were examined in vitro. Furthermore, the effects of LH-I and LH-II on the blood pressure were examined in spontaneously hypertensive rats （SHR）. The results showed that peptides and amino acids accounted for 70% or more of the constituents of both LH-I and LH-II. The results of gel filtration HPLC showed that most of the nitrogen-containing components were peptides or amino acids with molecular weights of 6000 or less. The DPPH radical scavenging activities of LH-I and LH-II were 55.6 and 38.1 μM Trolox Equivalent/g, respectively. The IC50 values for the ACE-inhibiting activity of LH-I and LH-II were 0.18 and 0.31 mg/mL, respectively. Oral administration of 1 g/rat of LH-I or LH-II to SHR resulted in significant lowering of the blood pressure. These findings indicate that both LH-I and LH-II have antioxidant activity and ACE-inhibiting activity. Moreover, both exerted a blood pressure-lowering effect in SHR. The antioxidant activity and ACE-inhibiting activity of LH-I and LH-II are presumed to be based on the actions of the component peptides. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : YAKUGAKU ZASSHI ja : 薬学雑誌 巻 133, 号 1, p. 107-115, 発行日 2013-01 |
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| 出版者 | ||||||
| 出版者 | 日本薬学会 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | The Pharmaceutical Society of Japan | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00316903 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
