@article{oai:miyazaki-u.repo.nii.ac.jp:00000458,
 author = {井上, 尚典 and Inoue, Naonori and 浜崎, 敦子 and 日高, 修二 and 三浦, 直良 and 深堀, 勝博 and Fukahori, Masahiro and Maruyama, Masugi and 丸山, 眞杉 and 河原, 聡 and Kawahara, Satoshi and 太田, 一良 and Ohta, Kazuyoshi and 六車, 三治男 and Muguruma, Michio and 井上, 尚典 and Inoue, Naonori and Hamasaki, Atsuko and Hidaka, Shuji and Miura, Naoyoshi and 深堀, 勝博 and Fukahori, Masahiro and Maruyama, Masugi and 丸山, 眞杉},
 issue = {1},
 journal = {YAKUGAKU ZASSHI, 薬学雑誌},
 month = {Jan},
 note = {Hypertension and oxidant stress predispose to the onset and progression of arteriosclerotic diseases. In this study, the components of two kinds of porcine liver hydrolysates （LH-I and LH-II） were analyzed, and the antioxidant effects and angiotensin converting enzyme （ACE）-inhibiting effects of LH-I and LH-II were examined in vitro. Furthermore, the effects of LH-I and LH-II on the blood pressure were examined in spontaneously hypertensive rats （SHR）. The results showed that peptides and amino acids accounted for 70% or more of the constituents of both LH-I and LH-II. The results of gel filtration HPLC showed that most of the nitrogen-containing components were peptides or amino acids with molecular weights of 6000 or less. The DPPH radical scavenging activities of LH-I and LH-II were 55.6 and 38.1 μM Trolox Equivalent/g, respectively. The IC50 values for the ACE-inhibiting activity of LH-I and LH-II were 0.18 and 0.31 mg/mL, respectively. Oral administration of 1 g/rat of LH-I or LH-II to SHR resulted in significant lowering of the blood pressure. These findings indicate that both LH-I and LH-II have antioxidant activity and ACE-inhibiting activity. Moreover, both exerted a blood pressure-lowering effect in SHR. The antioxidant activity and ACE-inhibiting activity of LH-I and LH-II are presumed to be based on the actions of the component peptides.},
 pages = {107--115},
 title = {ブタ肝臓水解物の成分分析と抗酸化活性及びアンギオテンシン変換酵素 (ACE) 阻害活性の検討},
 volume = {133},
 year = {2013},
 yomi = {イノウエ, ナオノリ and ハマサキ, アツコ and ヒダカ, シュウジ and ミウラ, ナオヨシ and フカホリ, マサヒロ and マルヤマ, マスギ and カワハラ, サトシ and オオタ, カズヨシ and ムグルマ, ミチオ and イノウエ, ナオノリ and フカホリ, マサヒロ and マルヤマ, マスギ}
}