WEKO3
-
RootNode
アイテム
Channel induction by palytoxin in yeast cells expressing Na+,K+-ATPase or its chimera with sarco/endoplasmic reticulum Ca2+-ATPase
http://hdl.handle.net/10458/1131
http://hdl.handle.net/10458/11311f7cd6cf-9337-4c94-ae67-7e3131da3b8f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FEBS543_108_2003.pdf (117.5 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-01-30 | |||||
| タイトル | ||||||
| タイトル | Channel induction by palytoxin in yeast cells expressing Na+,K+-ATPase or its chimera with sarco/endoplasmic reticulum Ca2+-ATPase | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Palytoxin, Na+,K+-ATPase, Channel, Catalytic domain, Yeast, Chimera | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
伊藤, 勝昭
× 伊藤, 勝昭× 伊藤, 勝昭× Toyoda, Isao× Higashiyama, Masato× Uemura, Daisuke× Sato, Masa H.× Yoshimura, Shige H.× Ishii, Toshiaki× Takeyasu, Kunio |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Palytoxin （PTX） induces a cation channel through interaction with Na+,K+-ATPase. It is unclear how this action relates to the enzyme catalytic activity. We examined whether the action of PTX depends on the catalytic domain specific for Na+,K+-ATPase. Wild-type Na+,K+-ATPase α-subunit （NNN） or its chimera （NCN）, in which the catalytic domain was replaced with that of SERCA, was co-expressed with β-subunit in the yeast Saccharomyces cerevisiae. PTX （0.1-100 nM） increased K+ efflux in NNN- or NCN-transfected cells to a similar degree but not in non-transfected cells. When ouabain-resistant NNN and NCN were expressed, PTX also increased K+ efflux. Ouabain inhibited the effect of PTX in NNN- or NCN-cells but not in ouabain-resistant cells. These data suggest that the channel-forming action of PTX does not depend on the catalytic domain species. |
|||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | <a href="http://www.febsletters.com/" target="_blank">Journal HP</a> | |||||
| 言語 | en | |||||
| 書誌情報 |
en : FEBS letters : for the rapid publication of short reports in biochemistry, biophysics and molecular biology 巻 543, 号 1-3, p. 108-112, 発行日 2003-05-22 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00145793 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00642943 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
Share
Cite as
伊藤, 勝昭, 伊藤, 勝昭, Toyoda, Isao, Higashiyama, Masato, Uemura, Daisuke, Sato, Masa H., Yoshimura, Shige H., Ishii, Toshiaki, Takeyasu, Kunio, 2003, Channel induction by palytoxin in yeast cells expressing Na+,K+-ATPase or its chimera with sarco/endoplasmic reticulum Ca2+-ATPase: 108–112 p.
Loading...
