@article{oai:miyazaki-u.repo.nii.ac.jp:00000859, author = {池田, 正浩 and Ikeda, Masahiro and 伊藤, 勝昭 and Ito, Katsuaki and Gunji, Yasuhiro and Sonoda, Hiroko and 園田, 紘子 and Oshikawa, Sayaka and Shimono, Mariko and Horie, Atsuko and 伊藤, 勝昭 and Ito, Katsuaki and Yamasaki, Shinji}, issue = {1-3}, journal = {European journal of pharmacology}, month = {Sep}, note = {The inhibitory effects of tyrosine kinase inhibitors including tyrphostin 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostin 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing Escherichia coli infectious diseases.}, pages = {36--39}, title = {Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death}, volume = {546}, year = {2006}, yomi = {イケダ, マサヒロ and イトウ, カツアキ and ソノダ, ヒロコ and イトウ, カツアキ} }