{"created":"2023-07-29T23:05:49.961447+00:00","links":{},"metadata":{"_buckets":{"deposit":"670455d7-2115-4917-a56a-511c66ba6d35"},"_deposit":{"created_by":9,"id":"859.4","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"859.4"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00000859.4","sets":["74","74:26"]},"author_link":["1081","1071","5450","5451","5452","5453","5454","5455","5456"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-09-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-3","bibliographicPageEnd":"39","bibliographicPageStart":"36","bibliographicVolumeNumber":"546","bibliographic_titles":[{"bibliographic_title":"European journal of pharmacology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The inhibitory effects of tyrosine kinase inhibitors including tyrphostin 25, 47 and 51 on\nShiga toxin 1-induced cell death and p38 mitogen-activated protein kinase （p38 MAPK）\nphosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga\ntoxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostin 25 and 51\nhad no significant effect on the Shiga toxin 1-induced responses. These data indicate that\nShiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the\ntarget molecule for tyrphostin 47 opens up new opportunities for pharmacological\nintervention against Shiga toxin-producing Escherichia coli infectious diseases.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.elsevier.com/wps/find/journaldescription.cws_home/506087/description"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/wps/find/journaldescription.cws_home/506087/description","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00639687","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00142999","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 正浩","creatorNameLang":"ja"},{"creatorName":"イケダ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikeda, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"伊藤, 勝昭","creatorNameLang":"ja"},{"creatorName":"イトウ, カツアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gunji, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sonoda, Hiroko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oshikawa, Sayaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimono, Mariko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horie, Atsuko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Katsuaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamasaki, Shinji","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"ejp-2006.pdf","filesize":[{"value":"547.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"EJP-2006.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/859/files/ejp-2006.pdf"},"version_id":"653a49c6-65a0-442f-978b-8da03d4ce0aa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Shiga toxin, p38 MAPK, tyrosine kinase, tyrosine kinase inhibitor, tyrphostin 47","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["74","26"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-01-29"},"publish_date":"2008-01-29","publish_status":"0","recid":"859.4","relation_version_is_last":true,"title":["Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2023-07-29T23:05:52.831642+00:00"}