@article{oai:miyazaki-u.repo.nii.ac.jp:00000859.3, author = {池田, 正浩 and Ikeda, Masahiro and 伊藤, 勝昭 and Gunji, Yasuhiro and Sonoda, Hiroko and Oshikawa, Sayaka and Shimono, Mariko and Horie, Atsuko and Ito, Katsuaki and Yamasaki, Shinji}, issue = {1-3}, journal = {European journal of pharmacology}, month = {Sep}, note = {The inhibitory effects of tyrosine kinase inhibitors including tyrphostin 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostin 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing Escherichia coli infectious diseases.}, pages = {36--39}, title = {Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death}, volume = {546}, year = {2006}, yomi = {イケダ, マサヒロ and イトウ, カツアキ} }