WEKO3
アイテム
Analysis of antibody response by temperature-sensitive measles vaccine strain in the cotton rat model
http://hdl.handle.net/10458/2879
http://hdl.handle.net/10458/287954f9a303-9929-4f23-a4e5-8f65bce828bb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2879-.pdf (616.5 kB)
|
|
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2010-05-26 | |||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||
| タイトル | Analysis of antibody response by temperature-sensitive measles vaccine strain in the cotton rat model | |||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| キーワード | Cotton rat, Measles vaccine, Temperature sensitive | |||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||
| 著者 |
Haga, Takeshi
× Haga, Takeshi× Murayama, Niho× Shimizu, Yuya× 齊藤, 暁
WEKO
33890
× Sakamoto, Takumi× Morita, Tetsuo× Komase, Katsuhiro× Nakayama, Tetsuo× Uchida, Kazuyuki× 片山, 徹郎
WEKO
6484
× 篠原, 明男
WEKO
5169
× 越本, 知大
WEKO
2792
× 佐藤, 寛× Miyata, Hironori× Katahira, Kiyoaki× Goto, Yoshitaka |
|||||||||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||||
| 内容記述 | Measles virus （MeV） vaccine strain, AIK-C, is temperature sensitive （ts）, which is thought to be associated with attenuation of virus pathogenicity. In this study, replication and antibody response were examined in cotton rats using viruses carrying different forms of the P gene, which is responsible for the ts phenotype of strain AIK-C and its parental Edmonston strain. When cotton rats were inoculated intranasally, ts viruses neither replicated in lungs, nor reproducibly generate an antibody response. When inoculated intramusculary （IM）, however, ts strains raised an antibody titer in all animals. This response was not observed when ultraviolet-inactivated virus was used. Ts virus, inoculated IM, was recovered from cotton rat drainage lymph nodes. These results suggest that ts virus, inoculated IM, could replicate in the cotton rat, presumably at the superficial lymph node, and induce an antibody response. Therefore, cotton rats can serve as a small-animal model for investigating immune responses to safer ts vaccine, as well as recombinant vaccine using AIK-C as a vector for protection against other infectious agents. | |||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| 書誌情報 |
en : Comparative immunology, microbiology and infectious diseases 巻 32, 号 5, p. 395-406, 発行日 2009-09 |
|||||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||
| 収録物識別子 | 01479571 | |||||||||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||
| 収録物識別子 | 18781667 | |||||||||||||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||||||
| 収録物識別子 | AA00612035 | |||||||||||||||||||||||||||||
| PubMed番号 | ||||||||||||||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||||||||
| 関連識別子 | 18249443 | |||||||||||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||||||||
