{"created":"2023-05-15T10:02:02.887741+00:00","id":6750,"links":{},"metadata":{"_buckets":{"deposit":"12b3e3ae-6020-4a10-b545-a608d8ab9504"},"_deposit":{"created_by":5,"id":"6750","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"6750"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00006750","sets":["72","72:30","76","76:64","79","79:42"]},"author_link":["9187","21835","9166","30742","9238","9416","34574","28014"],"control_number":"6750","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"88","bibliographicPageStart":"80","bibliographicVolumeNumber":"109","bibliographic_titles":[{"bibliographic_title":"Journal of Dermatological Science","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nPatients with smoldering ATLL often present with a skin eruption due to skin infiltration of ATLL cells. Although skin eruption type is known to be associated with prognosis based on its pattern, it is unknown why different types of skin eruptions are associated with different prognoses.\n\nObjective\nGenomic analysis of patients with skin eruptions of smoldering ATLL will be performed to determine the mechanism of ATLL development and its association with prognosis.\n\nMethods\nDNA from skin biopsy specimens was used for targeted sequencing of 280 genes to examine the association between genomic variation and prognosis.\n\nResults\nDue to the small number of smoldering ATLL patients （27 cases）, we could not find a clear relationship between skin eruption and prognosis in this study. Genomic analysis identified 247 genomic variants （108 genes）, with an average of 9.2 variants and 3.2 variants as driver genes. Pathway analysis of the driver genes showed activation of the pathway associated with HTLV-1 infection, as well as activation of the signaling pathway observed throughout ATLL. Furthermore, multivariate analysis identified age>70 years and STAT3 mutation as prognostic risk factors and TBL1XR1 mutation as a risk factor for progression-free survival.\n\nConclusion\nAlthough the small number of patient samples did not allow us to determine a prognostic association with skin eruption, STAT3 mutation was identified as a prognostic risk factor for smoldering ATLL with skin eruption. Further studies are needed to increase the number of patients with this disease.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jdermsci.2023.02.001","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's web site"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jdermsci.2023.02.001","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Authors. Published by Elsevier B.V. on behalf of Japanese Society for Investigative Dermatology."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09231811","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"井上, 健太郎","creatorNameLang":"ja"},{"creatorName":"イノウエ, 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genomic aberrations","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prognostic analysis of smoldering ATLL with skin eruptions based on genomic aberrations","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["72","76","79","30","64","42"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-26"},"publish_date":"2023-04-26","publish_status":"0","recid":"6750","relation_version_is_last":true,"title":["Prognostic analysis of smoldering ATLL with skin eruptions based on genomic aberrations"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-01-16T04:41:31.821533+00:00"}