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Social confrontation stress decreases hepatic fibroblast growth factor-21 expression in aged mice
http://hdl.handle.net/10458/00010598
http://hdl.handle.net/10458/000105987fa8d203-6e67-497b-b8c3-0c442a8541bd
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本文 (3.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2023-04-17 | |||||||||||
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| タイトル | Social confrontation stress decreases hepatic fibroblast growth factor-21 expression in aged mice | |||||||||||
| 言語 | en | |||||||||||
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| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| キーワード | Confrontation stress | |||||||||||
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| 言語 | en | |||||||||||
| キーワード | Mice | |||||||||||
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| 言語 | en | |||||||||||
| キーワード | Aging | |||||||||||
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| 言語 | en | |||||||||||
| キーワード | Fibroblast growth factor-21 | |||||||||||
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| 言語 | en | |||||||||||
| キーワード | Obesity | |||||||||||
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| 資源タイプ | journal article | |||||||||||
| 著者 |
榊原, 啓之
× 榊原, 啓之× 田中, 航× Matsuyama, Hiroki× Shimoi, Kayoko× 横山, 大悟
WEKO
34545
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| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | We previously showed that social stress exposure in mature adult mice increased blood corticosterone concentrations at 2 days, disrupted hepatic lipid metabolism-related pathway at 30 days, and increased the risk of overweight with hepatic hypertrophy at 90 days. To further investigate the effects of aging on the physiological responses to social stress, we conducted a study using male BALB/c mice at the ages of 2 months （mature age）, 14 months （middle age） and 26 months （old age）, and exposed them to confrontation stress for 2 or 7 days. Blood corticosterone concentrations were increased at 2 days of stress, and then returned to baseline concentrations. This change was observed only at 2 months of age. We further examined the effect of aging on hepatic gene expression of fibroblast growth factor-21 （Fgf21） and found that its expression was significantly decreased after 7 days of stress at 14 months of age and after 2 days of stress at 26 months of age, indicating these decreasing effects became more pronounced with age. In conclusion, our study suggests that hepatic Fgf21 expression decrease under exposure to confrontation stress at middle or more age, indicating that stress response on Fgf21 related pathway might be more pronounced with age when exposed to stress. | |||||||||||
| 書誌情報 |
en : Biochemistry and Biophysics Reports 巻 34, p. 101454, 発行日 2023 |
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| 出版者 | Elsevier | |||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 24055808 | |||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1016/j.bbrep.2023.101454 | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | © 2023 The Authors. Published by Elsevier B.V. | |||||||||||
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| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1016/j.bbrep.2023.101454 | |||||||||||
| 関連名称 | Publisher's web site | |||||||||||
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| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
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| 出版タイプ | VoR | |||||||||||
