{"created":"2023-07-29T07:58:33.610786+00:00","links":{},"metadata":{"_buckets":{"deposit":"627e58e4-f670-45a6-aa97-a1c53b5dc714"},"_deposit":{"created_by":5,"id":"6679.2","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"6679.2"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00006679.2","sets":["72","72:30"]},"author_link":["7768","8142","8158","34258","34267","34301","34266","34223","34265"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"102","bibliographicPageStart":"94","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Clinical and Experimental Nephrology","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nMedical intervention for patients with IgA nephropathy and mild proteinuria （<1.0 g/day） is controversial, and the effectiveness of tonsillectomy plus steroid pulse therapy （TSP） for such patients remains obscure.\n\nMethods\nAmong 323 patients in our multicenter cohort study, 79 who had mild proteinuria （0.4–1.0 g/day） at diagnosis were eligible to participate in this study. We compared the clinicopathological findings at diagnosis, a decline in renal function defined as a 50 or 100 % increase in serum creatinine （sCr） and clinical remission （CR） defined as the disappearance of hematuria and proteinuria （<0.3 g/day） among groups given TSP （n = 46）, steroid therapy （ST） （n = 9）, and non-ST （n = 24）. Factors contributing to CR were also evaluated using multivariate analysis.\n\nResults\nBackground factors at diagnosis including age, ratio （%） of patients with hypertension, sCr, proteinuria, and histological severity did not significantly differ among the groups. Only two patients each in the TSP （4.3 %） and non-ST （8.3 %） groups achieved a 50 % increase in sCr during a mean follow–up period of 4.7 years. At the final observation, 71.7, 44.4, and 41.7 % of patients in the TSP, ST, and non-ST groups, respectively, achieved CR （p = 0.032）. Cox proportional hazards models revealed that TSP led to CR more effectively than non-TSP by a factor of about threefold （hazard ratio, 2.74; p = 0.008）.\n\nConclusion\nTSP therapy has potential for inducing CR in patients with IgAN and mild proteinuria （<1.0 g/day）.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"26123429","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10157-015-1138-7","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's web site"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10157-015-1138-7","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(c) The Author(s) 2016. This article is published with open access at Springerlink.com"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13421751","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小松, 弘幸"},{"creatorName":"コマツ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Komatsu, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7768","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30598339","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30598339"}]},{"creatorNames":[{"creatorName":"藤元, 昭一"},{"creatorName":"フジモト, シヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimoto, Shouichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8142","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80173467","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80173467"}]},{"creatorNames":[{"creatorName":"Sato, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyamoto, Tetsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamura, Masahito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakata, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34301","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomo, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishino, Tomoya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34223","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyazaki, Masanobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34265","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-24"}],"displaytype":"detail","filename":"s10157-015-1138-7.pdf","filesize":[{"value":"563.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://miyazaki-u.repo.nii.ac.jp/record/6679/files/s10157-015-1138-7.pdf"},"version_id":"97df2448-7001-4763-8f71-9cd82f5eff77"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Significance of tonsillectomy combined with steroid pulse therapy for IgA nephropathy with mild proteinuria","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Significance of tonsillectomy combined with steroid pulse therapy for IgA nephropathy with mild proteinuria","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-02-24"},"publish_date":"2023-02-24","publish_status":"0","recid":"6679.2","relation_version_is_last":true,"title":["Significance of tonsillectomy combined with steroid pulse therapy for IgA nephropathy with mild proteinuria"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-06-01T23:44:28.053013+00:00"}