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Significance of tonsillectomy combined with steroid pulse therapy for IgA nephropathy with mild proteinuria
http://hdl.handle.net/10458/00010530
http://hdl.handle.net/10458/00010530204b0fcf-8bd1-4f3e-8a71-795522d655ea
| 名前 / ファイル | ライセンス | アクション |
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本文 (563.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-02-24 | |||||
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| タイトル | Significance of tonsillectomy combined with steroid pulse therapy for IgA nephropathy with mild proteinuria | |||||
| 言語 | en | |||||
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| 言語 | eng | |||||
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| 資源タイプ | journal article | |||||
| 著者 |
小松, 弘幸
× 小松, 弘幸× 藤元, 昭一× 佐藤, 祐二× Miyamoto, Tetsu× Tamura, Masahito× Nakata, Takeshi× Tomo, Tadashi× Nishino, Tomoya× Miyazaki, Masanobu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background Medical intervention for patients with IgA nephropathy and mild proteinuria （<1.0 g/day） is controversial, and the effectiveness of tonsillectomy plus steroid pulse therapy （TSP） for such patients remains obscure. Methods Among 323 patients in our multicenter cohort study, 79 who had mild proteinuria （0.4–1.0 g/day） at diagnosis were eligible to participate in this study. We compared the clinicopathological findings at diagnosis, a decline in renal function defined as a 50 or 100 % increase in serum creatinine （sCr） and clinical remission （CR） defined as the disappearance of hematuria and proteinuria （<0.3 g/day） among groups given TSP （n = 46）, steroid therapy （ST） （n = 9）, and non-ST （n = 24）. Factors contributing to CR were also evaluated using multivariate analysis. Results Background factors at diagnosis including age, ratio （%） of patients with hypertension, sCr, proteinuria, and histological severity did not significantly differ among the groups. Only two patients each in the TSP （4.3 %） and non-ST （8.3 %） groups achieved a 50 % increase in sCr during a mean follow–up period of 4.7 years. At the final observation, 71.7, 44.4, and 41.7 % of patients in the TSP, ST, and non-ST groups, respectively, achieved CR （p = 0.032）. Cox proportional hazards models revealed that TSP led to CR more effectively than non-TSP by a factor of about threefold （hazard ratio, 2.74; p = 0.008）. Conclusion TSP therapy has potential for inducing CR in patients with IgAN and mild proteinuria （<1.0 g/day）. |
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| 書誌情報 |
en : Clinical and Experimental Nephrology 巻 20, 号 1, p. 94-102, 発行日 2015 |
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| 出版者 | Springer | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13421751 | |||||
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| 識別子タイプ | PMID | |||||
| 関連識別子 | 26123429 | |||||
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| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s10157-015-1138-7 | |||||
| 権利 | ||||||
| 権利情報 | (c) The Author(s) 2016. This article is published with open access at Springerlink.com | |||||
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| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s10157-015-1138-7 | |||||
| 関連名称 | Publisher's web site | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | VoR | |||||
