{"created":"2023-05-15T10:01:57.745223+00:00","id":6652,"links":{},"metadata":{"_buckets":{"deposit":"205d5e05-8d22-4edd-8f77-faab401e9dba"},"_deposit":{"created_by":5,"id":"6652","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"6652"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00006652","sets":["72","72:30"]},"author_link":["34215","34218","34216","34223","34217","7768","69","34226","34222","8142","34220","34224","34225","34221"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"e0196955","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"PLOS ONE","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The clinical presentation and prognosis of adult and elderly patients with IgA vasculitis\n（Henoch-Scho¨nlein purpura） accompanied by nephritis （IgAV-N） have not been investigated\nin detail. We therefore surveyed the features and outcomes of IgAV-N based on nationwide\ndata derived from the Japan Renal Biopsy Registry （J-RBR）.","subitem_description_type":"Abstract"},{"subitem_description":"Methods: This multi-center cohort study compared the clinicopathological parameters at diagnosis,\ninitial therapies and outcomes between 106 adult （age 19–64 years） and 46 elderly （65\nyears） patients with IgAV-N who were registered in the J-RBR between 2007 and 2012. The\nprimary end-points comprised a 50% increase in serum creatinine （sCr） values or end-stage\nkidney disease. Factors affecting a decrease in renal function were assessed using Cox proportional hazards models.","subitem_description_type":"Abstract"},{"subitem_description":"Results: Rates of hypertension, impaired renal function, hypoalbuminemia and crescentic glomerulonephritis were significantly higher among the elderly, than the adult patients. About 80% and\n60% of the patients in both groups were respectively treated with corticosteroid and a reninangiotensin system （RAS） blockade. Both groups had favorable renal survival rates for nine\nyears （93.6% and 91.4% of the adult and elderly patients, respectively）. Significantly more\nelderly than adult patients developed a 50% increase in sCr during a mean observation\nperiod of 3.9 years （21.7% vs. 4.7%, p = 0.012）, and significantly fewer elderly, than adult\npatients achieved clinical remission （23.9% vs. 46.2%, p = 0.016）. Multivariate analysis\nselected advanced age （65 years） and lower serum albumin values as independent prognostic factors for a decline in renal function, whereas steroid pulse therapy helped to preserve renal function.","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions: The renal prognosis of adult and elderly patients with IgAV-N was favorable when treated\naggressively with corticosteroid and RAS blockade. However, the course of renal function\nshould be carefully monitored in patients aged over 65 years and those with hypoalbuminemia.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"29738576","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0196955","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Publisher's web site"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0196955","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 Komatsu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"小松, 弘幸","creatorNameLang":"ja"},{"creatorName":"コマツ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Komatsu, Hiroyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"小松","familyNameLang":"ja"},{"familyName":"コマツ","familyNameLang":"ja-Kana"},{"familyName":"Komatsu","familyNameLang":"en"}],"givenNames":[{"givenName":"弘幸","givenNameLang":"ja"},{"givenName":"ヒロユキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7768","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30598339","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30598339"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"藤元, 昭一","creatorNameLang":"ja"},{"creatorName":"フジモト, シヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimoto, Shouichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤元","familyNameLang":"ja"},{"familyName":"フジモト","familyNameLang":"ja-Kana"},{"familyName":"Fujimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"昭一","givenNameLang":"ja"},{"givenName":"シヨウイチ","givenNameLang":"ja-Kana"},{"givenName":"Shouichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8142","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80173467","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80173467"}]},{"creatorNames":[{"creatorName":"Maruyama, Shoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34215","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mukoyama, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34216","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugiyama, 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(J-RBR)","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-02-20"},"publish_date":"2023-02-20","publish_status":"0","recid":"6652","relation_version_is_last":true,"title":["Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schönlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registry (J-RBR)"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-01-07T04:51:33.100818+00:00"}