{"created":"2023-05-15T10:01:57.488043+00:00","id":6648,"links":{},"metadata":{"_buckets":{"deposit":"820cd8fd-b184-4471-9abc-344d339c2acd"},"_deposit":{"created_by":5,"id":"6648","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"6648"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00006648","sets":["72","72:30"]},"author_link":["7768"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"102","bibliographicPageStart":"95","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"宮崎県医師会医学会誌"},{"bibliographic_title":"The Journal of the Miyazaki Medical Association","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"IgA腎症は本邦を始め世界で最も頻度の高い原発性糸球体疾患であるが，最初の報告から約半世紀近くが経過した現在でも，発症機序は不明で疾患特異的な治療法は確立していない。2000年頃よりIgA腎症は腎予後不良な疾患として広く認識されるようになり，より精度の高い早期診断や重症度診断方法の確立，予後因子の探索，腎予後改善に繋がる治療方法の開発など，基礎的・臨床的研究エビデンスの集積が急務となっている。\n　宮崎大学では，特に2000年以降，自験例に基づくコホート研究を中心として継続的に研究成果を発信してきた。診断・重症度評価については，血清IgA/C3比や尿中ポドサイトmRNAsの有用性を検討してきた。疫学・予後については，治療反応限界閾（point of no return）の検討や若年と成人患者間の予後因子の比較，透析導入後IgA腎症患者の生命予後および長期維持透析患者の特徴を検討してきた。治療方法については，扁桃摘出術およびステロイド療法の腎予後改善効果や扁桃摘出術＋ステロイドパルス療法の尿所見寛解率向上への効果，これにレニン・アンジオテンシン系阻害薬を加えた併用療法の有用性を検討してきた。\n　本稿では，これまでの研究成果を領域毎にまとめつつ，最近の全国多施設との共同研究や全国データベースを用いた新たなリサーチ・クエスチョン解明への取り組みについても言及する。","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宮崎県医師会"}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"宮崎県医師会"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03898288","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"小松, 弘幸","creatorNameLang":"ja"},{"creatorName":"コマツ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Komatsu, Hiroyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"小松","familyNameLang":"ja"},{"familyName":"コマツ","familyNameLang":"ja-Kana"},{"familyName":"Komatsu","familyNameLang":"en"}],"givenNames":[{"givenName":"弘幸","givenNameLang":"ja"},{"givenName":"ヒロユキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7768","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30598339","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30598339"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-16"}],"displaytype":"detail","filename":"400202.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://miyazaki-u.repo.nii.ac.jp/record/6648/files/400202.pdf"},"version_id":"906a3ab3-7314-42bf-976a-bfa68ebf85cd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"IgA腎症の現状と宮崎大学の取り組み","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IgA腎症の現状と宮崎大学の取り組み","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-02-20"},"publish_date":"2023-02-20","publish_status":"0","recid":"6648","relation_version_is_last":true,"title":["IgA腎症の現状と宮崎大学の取り組み"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-06-01T23:49:25.678032+00:00"}