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Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica ‘Irwin’): 90-days oral toxicity study in rats
http://hdl.handle.net/10458/00010425
http://hdl.handle.net/10458/00010425459d7add-9104-4dae-874a-8a6b8ceaee77
| 名前 / ファイル | ライセンス | アクション |
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Full Text (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2022-11-08 | |||||
| タイトル | ||||||
| タイトル | Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica ‘Irwin’): 90-days oral toxicity study in rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | No-observed-adverse-effect level (NOAEL) | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Oral toxicity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Rats | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Subchronic toxicity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Thinned immature mango | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
榊原, 啓之
× 榊原, 啓之× Tajiri, Hayato× 田中, 航× Takashima, Masakatsu× Matsuyama, Hiroki× Sugita, Takuya× Hidaka, Kenta |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Thinned immature fruit of the mango tree （Mangifera indica ‘Irwin’） are handled as waste. In this study, we conducted a 90-days toxicity study in male and female Sprague Dawley rats to evaluate the safety of a hot-water extract of thinned immature mango fruits （TIMEx） administered by oral gavage at doses of 500, 1000 and 2500 mg/kg body weight/day. Treatment did not result in death or changes in the behavior or external appearance of the animals. No alterations were observed in hematological or serum chemical parameters, urinalysis, food consumption, body weight gain or organ weights at the end of the treatment period, with the exception of higher mean corpuscular volume in male rats that received high doses and lower serum creatine phosphokinase levels in female rats that received medium doses. Under the conditions of this study and based on the toxicological endpoints evaluated, the no-observed-adverse-effect level （NOAEL） for TIMEx was 2500 mg/kg/day. The findings indicate that TIMEx is safe for consumption and should be investigated as a candidate food. | |||||
| 書誌情報 |
en : Toxicology Reports 巻 8, p. 1046-1053, 発行日 2021 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 22147500 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.toxrep.2021.05.005 | |||||
| 権利 | ||||||
| 権利情報 | © 2021 The Authors. Published by Elsevier B.V. | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | VoR | |||||
