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Characterization of putative tachykinin peptides in Caenorhabditis elegans
http://hdl.handle.net/10458/00010423
http://hdl.handle.net/10458/00010423f86ef2fb-c1bd-4297-8ad7-8fe3444b124f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-11-07 | |||||
| タイトル | ||||||
| タイトル | Characterization of putative tachykinin peptides in Caenorhabditis elegans | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | GPCR | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Novel bioactive peptide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | C. elegans | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Tachykinin | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
井田, 隆徳
× 井田, 隆徳× Sakai, Naoko× Ohno, Hayao× Yoshida, Morikatsu× Iwamoto, Eri× Kurogi, Akito× 姜, 丹鳳× Sato, Takahiro× Miyazato, Mikiya× Kojima, Masayasu× 加藤, 丈司 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Tachykinin-like peptides, such as substance P, neurokinin A, and neurokinin B, are among the earliest discovered and best-studied neuropeptide families, and research on them has contributed greatly to our understanding of the endocrine control of many physiological processes. However, there are still many orphan tachykinin receptor homologs for which cognate ligands have not yet been identified, especially in small invertebrates, such as the nematode Caenorhabditis elegans （C. elegans）. We here show that the C. elegans nlp-58 gene encodes putative ligands for the orphan G protein-coupled receptor （GPCR） TKR-1, which is a worm ortholog of tachykinin receptors. We first determine, through an unbiased biochemical screen, that a peptide derived from the NLP-58 preprotein stimulates TKR-1. Three mature peptides that are predicted to be generated from NLP-58 show potent agonist activity against TKR-1. We designate these peptides as C. elegans tachykinin （CeTK）-1, −2, and −3. The CeTK peptides contain the C-terminal sequence GLR-amide, which is shared by tachykinin-like peptides in other invertebrate species. nlp-58 exhibits a strongly restricted expression pattern in several neurons, implying that CeTKs behave as neuropeptides. The discovery of CeTKs provides important information to aid our understanding of tachykinin-like peptides and their functional interaction with GPCRs. | |||||
| 書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 559, p. 197-202, 発行日 2021 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006291X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2021.04.063 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/am/pii/S0006291X21006434 | |||||
| 関連名称 | 本文 | |||||
